Tag Archives: Alzheimer’s disease

Natural addiction treatment

Greatest aging fear faced by many

Greatest aging fear

Greatest aging fear faced by many is loss of memory and problems relating to Alzheimer’s

Greatest aging fear faced by many: Alzheimer’s

I may not know what is going on in your mind about your daily activities. But one common thing is that the greatest aging fear faced by many is Alzheimer. Just to share about myself, there are days that I am too forgetful. At one time I misplace my reading glasses, forget names as soon as I am told or pull up into my home garage after work only to remember that I forgot to stop and pick up something for dinner on the way home. Like I had said, I don’t know about you but if this sounds all too familiar, it may interest you to note that although up to 80 percent of your risk of Alzheimer’s is related to genetic factors, your risks of this can be modified by a few toxic exposures and lifestyle adjustments reiterates doctor Dalal Akoury MD President and founder of AWAREmed Health and Wellness Resource Center.

While it may sound too good to be true, think of it this way: Correcting hormone imbalance takes care of the brain, so it can take care of your mind, and by extension, you. The best news of all is that you don’t need to take medication to stave off memory loss. You can start now without any major investment. Here are a few things that I found through my research help keep your brain and mind sharp:

Greatest aging fear faced by many: Having good sleep of between 7-8.5 hours

 Many have their reasons for ignoring good night’s sleep. But whatever the reason, it doesn’t change the fact that good night sleep is like a shampoo for your lymphatic system, which keeps blood sugar in check and banishes brain fog. It also keeps your mind sharp, by keeping cortisol in check so stress doesn’t get the best of you. Did you know that? Now you know.

Greatest aging fear faced by many: Staying stimulated

Like your body, your brain needs a workout regimen. Adult education has been shown to reduce the risk of dementia by 75%. Playing word games, doing crossword puzzles, and staying up on current events can help keep your mind sharp for years to come. Dear friend this is doable at home, don’t you think so?

Greatest aging fear faced by many: Find your community

Interacting with others stimulates the brain. According to a researcher from Harvard, it was established that people with at least five social ties like religious or social groups, regular visits, or phone calls with family and friends, were less likely to experience cognitive decline than those with no social ties. We are still talking about rejuvenating your memory and it is helpful noting how simple things can work well for you. Losing memory can really bring you down and the sooner you take action the better for you and your loved ones. You can seek for more professional insight by scheduling an appointment with doctor Akoury now.

Greatest aging fear faced by many: Alzheimer’s

http://www.awaremed.com/wp-admin

 

 

Facebooktwittergoogle_pluspinterestlinkedin

Alzheimer’s Disease Treatment & Care

Alzheimer’s Disease Treatment in Myrtle Beach, SC

Alzheimer’s is a type of dementia that causes problems with memory, thinking and behavior. Symptoms usually develop slowly and get worse over time, becoming severe enough to interfere with daily tasks. Alzheimer’s disease a type of dementia, resulting in loss of brain function. Alzheimer’s Disease is caused by the aging process. Alzheimer’s disease affects your thinking capacity, memory and behavior. Alzheimer’s disease is characterized by progressive deterioration of the patient’s cognitive and memory functions.

alzheimer's disease treatment

Alzheimer’s is not a normal part of aging, although the greatest known risk factor is increasing age, and the majority of people with Alzheimer’s are 65 and older. But Alzheimer’s is not just a disease of old age. Up to 5 percent of people with the disease have early onset Alzheimer’s (also known as younger-onset), which often appears when someone is in their 40s or 50s

Symptoms of Alzheimer’s disease include serious mental dysfunction including:

  • Emotional liability and behavior abnormalities
  • Personality Change
  • Language impairment
  • Perception distortion
  • Thinking abnormality
  • Judgment impairment
  • Memory lapse

Alzheimer’s disease can also present by:

  • Change in sleep patterns
  • Delusions
  • Depression
  • Aggression
  • Agitation
  • Hallucinations
  • Forgetfulness

Alzheimer’s has no current cure, but treatments for symptoms are available and research continues. Although current Alzheimer’s treatments cannot stop Alzheimer’s from progressing, they can temporarily slow the worsening of dementia symptoms and improve quality of life for those with Alzheimer’s and their caregivers. Today, there is a worldwide effort under way to find better ways to treat the disease, delay its onset, and prevent it from developing.  There’s no known cure for Alzheimer’s, and treatment consists of therapies designed to slow the progression and manage its symptoms. Together with numerous available prescription drugs, integrative medicine options are available as complementary treatments. The detection of early onset of Alzheimer’s disease can result in better effectiveness of the treatment options. If you or someone you love is beginning to show early signs of Alzheimer’s disease call for help!

To request more information, please call (843) 213-1480 or contact online.

Facebooktwittergoogle_pluspinterestlinkedin

What Causes Neurodegenerative Changes

What Causes Neurodegenerative Changes

Neurodegeneration is a medical condition of the nerve system that generally refers to a gradual loss of neurons. It is a condition of damage to the nerve cells both in structure and functionality. Neurodegeneration changes also used to refer to the death of nerve cells. It is an age related condition of the brain. Neurodegeneration is however a blanket terminology. It involves several disorders. Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS), Corticobasal Degeneration (CBD), HIV-related cognitive impairment, and Huntington Disease (HD) are just but a few.

  1. Alzheimer’s Disease (AD)

This is degenerative brain condition that gradually erodes memory. Alzheimer’s disease AD distorts one’s ability to think clearly. It is characterized by progressive failure to solve simple numerical problems and inability to perform simple tasks. AD is reportedly the root cause of dementia. Based on several research findings, AD accounts to close to 70 percent of all cases of the brain disease. AD is one of the neurodegenerative changes that increase exponentially with age. It is even reported the number of Americans with the AD condition stands at well over 5.1 million. For an in-depth explanation of the disease please click on www.awaremednetwork.com.

AD is a genetically inherited condition. Chances of inheriting the disease are however minimal, at a low of 5% or less. Signs of the disease often begin to show at an age, 65. However there are forms of AD that can indicate early signs at as low as age 30. Early-onset Familial Alzheimer’s Disease (EOFAD) is one such. There are genetic materials that can increase or reduce proneness of a person to the disease but do not necessarily cause it. You may call up Dr. Dalal Akoury of integrative Addiction Institute and International Organization of Integrative Cancer Physicians for incisive information on genetic composition of AD and its transmission through generations.

nerve degeneration

Naturally the first sign of Alzheimer’s Disease (AD) is loss of memory especially about recent events. Memory lapses may also occur however not profound. An example of a person suffering early signs of these neurodegenerative changes is one asking the same thing over and over, even when that same question has been properly answered in recent prior conversations. While at home they struggle to find such small items like handkerchiefs or wallets. Ever wondered why some people constantly leave foods on the cooker? AD victims are actually worse in the kitchen. Their foods always burn. The disease often progresses from mild AD, Moderate AD to advanced stages of the Neurodenerative changes of Severe Alzheimer’s Disease. Eee…very crazy, I guess many of us are victims. This is why you must sign up for this year’s August integrative addiction medicine conferences. Click on http://www.integrativeaddiction2015.com for more information.

  1. Amyotrophic Lateral Sclerosis (ALS)

This is a degenerative brain condition that often affects the motor neurons in adults. It is one of the most common forms of neurodegenerative changes in the U.S. Amyotrophic Lateral Sclerosis (ALS) often causes a discerned loss of neurons that normally connects the brain to the muscles. It affects both the dorsal superior motor neurons and the lower inferior neurons of the spinal cord in the rest of the body. This condition is well very popular in the U.S. according to population studies, the figures stand at an astonishing 5600 patients each calendar year, with well over 15 new victims every single day. Men are reportedly 20% more prone to this type of degenerative change compared to women. You may click on www.awaremednetwork.com to further research on ALS and the other neurodegenerative changes. Dr. Akoury will be of great assistance too in understanding genetic composition and transmission of the ALS.

Basic symptom of ALS involves a feeling of weakness in the arms. Other symptoms include clumsiness, stiffness, and slowness. Muscles in the said organs often become smaller as the disease progresses. Other symptoms; cramping and twitching even though are common in much healthier people, tend to be profound when one is nursing ALS. It is for the same reasons the degenerative change is normally ignored in its primary stages. ALS does not uniformly progress from one stage to the other in every victim. The disease is however worse at an advanced stage, paralysis. There are not specific laboratory tests to ALS however low co-ordination between the fine motor neurons always serves a good one. Again, there are various professionals attending this year’s August integrative addiction medicine conference, catch some of them via the above link. The speakers are carefully selected to handle a number of subjects across a wider array of medical problems you might be interested in knowing treatment of such neurodegenerative changes.

  1. Corticobasal Degeneration (CBD)

CBD is sometimes called Corticobasal ganglionic degeneration (CBGD). Clinically, It is similar FrontoTemporal Dementia (FTD). Just like the AD above, CBD is also characterized by loss of neurons and contraction of certain parts of the brain among them; the basal ganglia and the cerebral cortex. The disease is more often diagnosed in patients within the age brackets of 45 and 70. CBD is hardly genetically transmitted down the generations. The symptoms vary from locomotive difficulties to cognitive discrepancies. They are usually very unique. It is therefore advisable to refer suspected patients to a practitioner with good experience with the disorder. Consistent advances in scientific studies and research have led to a better understanding of CBD among other neurodegenerative changes hence improved medical care and therapeutic interventions.

NEURODEGENERATIVE changes

  1. Frontotemporal Dementia (FTD)

This is a cluster of related neurodegenerative changes resulting from progressive deterioration of the temporary and font lobes of the human brain. In a case similar to that of AD, FTD greatly affects decision making, emotional control, speech and general behavior of the patient.

Frontotemporal dementia is a cluster of related conditions resulting from the progressive degeneration of the temporal and frontal lobes of the brain. These areas of the brain play a significant role in decision-making, behavioral control, emotion and language.

  1. HIV-related Cognitive Impairment

Thanks to antiretroviral interventions, effects of Human Immunodeficiency Virus (HIV) on the nervous system have declined. Few cases however still exist. HIV- related impairments can be broadly categorized into Asymptomatic neurocognitive impairments, mild neurocognitive disorder, and HIV-associated dementia (HAD). The first two categories barely have any visible symptoms. However the third category, HAD has from time to time indicated severe effect on the victims both clinically and on their daily life activities. As earlier mentioned, cases of HAD are however rare. The other form of neurodegenerative change is the Huntington Disease (HD), which affects the underlying neurons of the brain. You may visit any of the above links for more information on HD and the other neurodegenerative changes. Once again click http://www.integrativeaddiction2015.com for your chance to participate in the integrative addiction medicine conference mentioned earlier.

Neurodegenerative Changes

Facebooktwittergoogle_pluspinterestlinkedin

Neuroplasticity In The Mesolimbic Dopamine System And Cocaine Addiction

Neuroplasticity In The Mesolimbic Dopamine System And Cocaine Addiction

Cocaine is the most addictive of all forms substance abuse. It is characterized by a high compulsion and relapse. Despite several years of clinical research, scientists are yet to find an effective medication. However some studies indicate the activity of neurons in the mesolimbic dopamine system, which comprises cells in the Ventral Tegmental Area (VTA) that develop into the medial and detour prefrontal cortex, amygdala, and accumbent, motivates cocaine reward thereby contributing to high compulsion.

Based on these research activities often called neuropharmacological studies, the addiction of cocaine is caused by neuroadaptations induced by the drug. This is so reportedly because of the learning, reward-related and memory processes of the mesolimbic dopamine systems’ circuitry where dopamine projections are developed.

Neuroadaptation Cause of Cocaine Compulsion

Neuroadaptations are understood to cause very high sensitivity to cocaine. They are also believed to cause hypersensitivity to cocaine-associated electrochemical signals such as irrational decision making and irregular cultured behaviors characterized by high insensitivity to dire consequences of addiction.           A major characteristics of cocaine addiction is its’s compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. A current popular hypothesis is that compulsive cocaine use and cocaine relapse is due to drug-induced neuroadaptations in reward-related learning and memory processes, which cause hypersensitivity to cocaine-associated cues, impulsive decision making and abnormal habit-like learned behaviours that are insensitive to adverse consequences. Here, we review results from studies on the effect of cocaine exposure on selected signalling cascades, growth factors and physiological processes previously implicated in neuroplasticity underlying normal learning and memory. These include the extracellular signal-regulated kinase (ERK) signalling pathway, brain-derived neurotrophic factor (BDNF), glutamate transmission, and synaptic plasticity (primarily in the form of long-term potentiation and depression, LTP and LTD). We also discuss the degree to which these cocaine-induced neuroplasticity changes in the mesolimbic dopamine system mediate cocaine psychomotor sensitization and cocaine-seeking behaviours, as assessed in animal models of drug addiction. Finally, we speculate on how these factors may interact to initiate and sustain cocaine psychomotor sensitization and cocaine seeking.

mesolimbic dopamine system

The premise that cocaine has a neuroadaptation effect to the chemical composition of certain parts of the brain has motivated various studies on the part of cellular actions and signaling forces that altogether causes neuro-synaptic plasticity. Effects of long-term exposure to cocaine on signaling forces, growth elements, psychosocial and physiological processes of reward transmission initially linked to neuroplasticity as a cause of mental recovery are a substantial number. They include extracellular-controlled kinase, distortion of normal neuron pathways and other neurotrophic factors, neuro-synaptic plasticity, and glutamate factors.

Neuroplasticity in Mesolimbic Dopamine System  

Neuroplasticity is the brain’s ability to adjust to new environments or needs by developing new nerve cells throughout the body. It is the brain’s way of recovery. Neuroplasticity allows the cells to compensate for any injuries or diseases in the nerve system. It also allows the neurons reorganize themselves to perform new functions of the brain depending on changes in their working environment, also involves recovery from drug addiction such as that of cocaine.

Cocaine-induced neurochemical changes in glutamate transmissions and synaptic plasticity in the mesolimbic dopamine system facilitates cocaine psychomotor high sensitivity, compulsion, self-injection, and reinstatement, being interesting aspects of study in shedding light into cocaine addiction menace has been reviewed time and again.

Experimental Evidence of Neuroplasticity on Long-Term Exposure to Cocaine

A key consideration in the above reviews has been what experimental evidence are needed to derive a conclusion of the particular effects of long-term exposure to cocaine on neuroplasticity and how those effects facilitate the learned behavioral symptoms associated with that.

Given this objective, researchers made a strict condition that if so cocaine-induced neuroplasticity causes certain attributer learned behavior then a reversal of the physiological processes that led to that state should, therefore, guarantee a reduced exhibition of such behavior.

After further intense studies on the same, the condition is continuously being met. This has led to yet another attempt to evaluate the role of cocaine-induced neurochemical alterations in glutamate transmissions, synaptic plasticity in VTA, accumbens and amyglada in as earlier mentioned psychomotor hypersensitivity and compulsive behavioral characteristic of the drug.

Many of those studies found out repeated cocaine administration amplified the rate of activity of ERK in the development areas of the mesolimbic dopamine system, which includes the accumbens, amygdala and the prefrontal cortex of the brain.

ERK Phosphorylation in Mesolimbic Dopamine System

Triggers of increased ERK phosphorylation includes D1 dopamine receptors, (PKA) the dependent protein kinase and methyl-D-aspartic acid (NMDA). On the other hand it was observed triggers of reduced ERK phosphorylation include CREB the transcription factor, mitogen-and stress-activated protein kinase-1 (MSK-1), and immediate early genes Fos and Zif268.

Extracellular signal-controlled kinase activity and the subsequent ERK-mediated reduced gene transcription are crucial for increased cocaine-induced psych as a result of exposure to the drug. On the other hand increased cocaine-induced ERK activity in the mesolimbic dopamine system does not facilitate the development of psych after a considerable time of withdrawal. Injection of either SL327 or VTA therefore before cocaine administration lessens sensitized the drug-induced movement during experimental tests for expression of psychomotor sensitization if done some time after withdrawal.

mesolimbic dopamine system

Cocaine Psychomotor Sensitization

More recent reports indicated psychomotor cocaine sensitization after several weeks of withdrawal from the drug increased ERK2 activity. This was linked to increased acumen α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and the receptor’s (AMPAR’s) surface appearance. However, no increases in ERK2 activity nor AMPAR surface expressions were observed in the specimens that did not exhibit psychomotor cocaine sensitization even after repeated non-dependent cocaine exposure and after some time of withdrawal.

Acumen’s ERK rate of activity possibly serves two specific roles in facilitating rewarding effects of the psychostimulant in a CPP procedure. During CPP training, the accumben’s rate of activity mediates consolidation of the learned behavior between the drug’s unconditioned rewarding effects and the drug’s related context during the CPP testing, ERK movement mediates serious expression of cocaine’s other habituated responses.

Systemic SL327 inoculations before cocaine CPP training prevented cocaine-induced accumbens, ERK phosphorylation and the subsequent expression of cocaine CPP. PD98059 accumben injections are given either before or after CPP training sessions blocked subsequent amphetamine CPP expression.

The relevance of the above fascinating correlational findings of cocaine’s compulsive characteristic, its’ psychomotor sensitization, and the ERK phosphorylation in the mesolimbic dopamine system is, however, a subject for further scientific, clinical research. Please sign up for this year’s August Integrative Addiction Medicine Conference to learn more about the same. Click the following link to get your chance to participate in the event: http://www.integrativeaddiction2015.com.

Neuroplasticity In The Mesolimbic Dopamine System And Cocaine Addiction

Facebooktwittergoogle_pluspinterestlinkedin

Allogeneic Stem Cells For Neurodegenerative Diseases

Allogeneic Stem Cells Role in Neurodegenerative Diseases

stem cellThe stem cells are the precursors of all cells in the body. They are very essential for formation of new tissues and healing of damaged tissues as a result of diseases or even accidents. The stem cells are available in adequate quantities in the bone marrow and in the adipose tissues as well. They have the ability to turn into the red blood cells, platelets or even the white blood cells. They can also form the muscles cells, the bones and even cartilage and hence help in keeping your body healthy. naturally you should be having the healthy amounts of these stem cells, unfortunately due to diseases and accidents that may result in bone marrow destruction and damage you may have too little of these essential stem cells and so you will need a stem cell transplant. In most cases the stem cell transplant is done through an IV, supplementing the little stem cells you have left and hence enabling the body to work right.

When the stem cells are harvested from the same person, the transplant is termed as autologous stem cell transplant. the autologous stem cell transplant is the most popular as the cells are harvested from the patient’s own body and this rules out any chance of the transplant being rejected or causing any pathological reactions that may warranty serious medical attention. however there are cases when the stem cells can’t be sourced from the patient’s own body and this will dictate that the stem cells be sourced from a different person who is not genetically identical to the patient; this is termed as allogeneic stem cell transplant. For safety of any recipient in allogeneic stem cell transplant, it is important to match closely the immune system markers to reduce chances of any reaction that may inhibit the healing process.

Stem cells and neurodegenerative diseases

Neurodegenerative diseases are numerous and each has distinctive effects on the patient but all are caused as a result of neurodegeneration. Neurodegeneration refers to the damage of the nerves in that are essential for transmission of messages within the nervous system. When the nerve cells are destroyed and deformed, they lose their original structure they will begin to malfunction. In most cases this damage is done gradually but at the end of it all the patient will suffer from cognitive disabilities such as memory loss and poor decision making. There are numerous neurodegenerative diseases, however basing on their debilitating effects, just a few have been known and are being currently focused on. Some of the famous neurogenerative diseases includes; Huntington disease, Parkinson’s disease and Alzheimer’s disease. Apart from these diseases listed above there are others that have not been in the medical literature and are less publicized, this doesn’t mean that they are not worth the mention. They are.

The greatest danger of all neurodegenerative diseases is that they lead to progressive brain damage and neurodegeneration. The major three diseases may show different features and effects but they progress in similar manner at the cell level. take Parkinson’s disease for example, it affects the basal ganglia of the brain, depleting it of dopamine hence causing stiffness, rigidity and tremors in the major muscles of the body which are distinctive features of the disease.

In Alzheimer’s disease, it is characterized by deposits of minute protein plaques that damages different brain parts thereby leading to gradual memory loss while Huntington’s disease is known to corrupt the genetic make-up affecting muscles of the body thereby resulting in motor restriction and eventual death.

Allogeneic stem cells transplant

Allogeneic stem cellsThe cell is harvested from the bone marrow of a suitable donor by use of a needle. This maybe done repeatedly to draw the sufficient amounts needed for the transplant. After harvesting the cells from the marrow the blood is passed through a machine that separates the stem cells from the blood leaving the rest of the blood flowing back into the donor through the needle into the donors arm. The harvested stem cells can then be transplanted into the patient through a central venous catheter that is inserted into the patient’s chest. The stem cells flow through the catheter into the patient’s blood and into the bone marrow where they will give rise to other stem cells between one to three weeks.

After transplant the stem cells will begin to work in repairing and replacing the worn out tissues caused by various degenerative diseases. All this is made possible since they can form any cell in the body and help restore the normal body functions.

The neurodegenerative diseases have very debilitating effects; the inception of stem cell therapy seems to be a light at the end of the tunnel for those suffering from these diseases. Anyway you need to be updated on how well you can regain your health and vitality back even after suffering from these diseases.

conference

Get in contact with Dr. Dalal Akoury an experienced doctor in integrative medicine at www.awaremednetwork.com as well as http://www.integrativeaddiction2015.com and learn more about the upcoming Integrative Addiction Conference 2015. The conference will focus on the unique approaches to identifying symptoms of addiction and how to help addicts.

Allogeneic Stem Cells Role in Neurodegenerative Diseases

 

Facebooktwittergoogle_pluspinterestlinkedin