Before you make a decision to go through autologous stem cell procedure, it is advisable to understand the risk behind it. Recent studies have shown that a child who has a family history related to inherited leukemia, sickle cell disease or black diamond fan is in danger of having a complication that might require a stem cell transplant. However, the probability might be low or high depending on several factors.
For example, there is a low chance of one in 20, 000 for families who don’t have any history related to any of the inherited complications. This can be evident in the finding that the autologous cord blood stem cell’s documented cases to date are only five.
There has been a lot of debates revolving around the use of autologous stem cells despite its proven benefits. The transplantation of autologous stem cell has been known to work well for several types of solid as well as hematological tumors.
According to an overview by Gradwohl et al., 2001, in the year 1999, 69% 18, 720 initial transplants were autologous. The 69% included up to 6,289 leukemia transplants, 8,219 lymphoma transplants, and 3,302 solid tumor transplants.
According to recent findings, these figures have increased significantly in the previous years. The main concern is not based on whether the transplantation of autologous progenitor cell has a purpose, but whether the cord blood will produce enough autologous cells in the coming years.
Among the controversies is an issue that questions several blood complications where the defect is related to genes and that can prevent the performance of autologous stem cells in therapy. According to a review by, Greaves, 2002, 1% of up to 600 samples of blood showed the existence of TEL-AML1 fusion gene that is known to be related to leukemia. It is apparent that up to 100% of those with this type of genes are at great risk. It is also apparent that these pre-leukaemia mimickers can’t be converted for a benefit.
The controversies behind the use of autologous cord blood are known to be influenced by the fact that most families prefer storing the cord blood after birth with an intention of using it to help the child’s sibling in future.
Among the victims are the siblings that are supposed to go through cardiac transplantation where the cellular cardiomyoplasty may be a requirement in the coming years. Another good example is a family with diabetic history who decided to keep the cord blood of their child for security following the research findings that the stem cell that is based on gene therapy may be cure diabetes.