Obesity addiction
Hypothalamic pituitary adrenal

Hypothalamic pituitary adrenal axis a weight loss motivating factor

Hypothalamic pituitary adrenal axis: Upper body obesity

The HPA (Hypothalamic Pituitary Adrenal axis) axis is one of two major neuroendocrine systems associated with the stress response. Corticotrophin-releasing hormone (CRH), secreted from the Para-ventricular nucleus (PVN) of the hypothalamus, stimulates the synthesis of adrenocorticotropic (ACTH) from the anterior pituitary gland. Other hypothalamic ACTH secretagogues are arginine vasopressin and oxytocin, also produced in the PVN. Physical stressors such as hypoglycemia, hemorrhage, and immune stimuli activate PVN neurons expressing arginine vasopressin and CRH. ACTH stimulates cortisol production from the adrenal cortex. And according to the experts at AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD, There is clear evidence that cortisol levels may be related to obesity and metabolic disease and that is based on clinical observations of Cushing’s syndrome; the pathological hypercortisolemia in Cushing’s syndrome is associated with UBO, glucose intolerance [impaired glucose tolerance (IGT)], and hypertension. Adrenalectomy in Cushing’s syndrome patients reverses IGT and obesity. Research findings in the last decade has demonstrated that obesity and metabolic syndrome are characterized by chronic inflammation.

Fetal programming, stress, and obesity

Stress experienced in early life may also be a risk factor in the development of obesity and metabolic syndrome. A study on nonhuman primates reported that juvenile bonnet macaque monkeys exhibit greater weight, BMI, waist circumference, and insulin resistance if their mothers are exposed to food insecurity when the monkeys are young (age 3–5 months) further explaining why stress is a serious factor.

Sleep deprivation and obesity

In the past 30 years, the average nightly sleep duration has decreased from 8–9 to 7 h per night. Currently, 30% of all adults in the USA sleep less than 6 h per night. Sleep deprivation has been linked to both increased risk for obesity. Epidemiological studies have reported a negative association between BMI and sleep duration in adults and, children. Sleep deprivation is suggested to be a chronic stressor that may contribute to increased risk for obesity and metabolic diseases, possibly in part through HPA axis dysregulation, although the data are inconsistent. Sleep deprivation resulted in decreased night-time and morning plasma cortisol levels, or increased night-time plasma cortisol levels in other studies.

Finally, from the professional desk at AWAREmed health center, the current review provides basic support for the relationship between chronic stress, alterations in HPA activity, and obesity. Although animal models provide evidence of the association of stress, HPA axis, and metabolic diseases, human studies have proven to be more challenging, with more understated changes in the HPA axis. Therefore, for us to be safe from all these research findings, we have a duty to place both individually and collectively. And because of this, doctor Akoury established this health center to help in the transformation of people’s lives through increasing awareness about health and wellness and by empowering individuals to find their own inner healing power. Besides that, it will interest you to note that doctor Akoury’s practice focuses on personalized medicine through healthy lifestyle choices that deal with primary prevention and underlying causes instead of patching up symptoms making her the best for you and your loved ones. You can schedule an appointment with her on telephone number 843 213 1480 for the commencement of your recovery process.

Hypothalamic pituitary adrenal axis: Upper body obesity

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