Treatment of cancer involves the doctors analyzing some of the research findings and drug test results to give a patient a preferable cancer treatment that is thought of as the best for the type of cancer he or she has. The essence of personalized cancer treatment has attracted the attention of many doctors and the Research Genetic cancer center have adopted a test; chemosensitivity testing that may help them know which treatment is good for a patient depending on the state and type of his cancer.
Chemosensitivity testing helps the doctors to know which drugs are good for your type of cancer. It involves extraction of the individual’s cancer cells and testing the cancer cells in lab to see which drug they are most responsive to. The chemosensitivity testing offers a guide to the doctors on which treatment methods to implement when treating the patient.
Chemosensitivity is more strategic and not haphazard and so is most effective as the drugs and the treatment procedures the patient is subjected to are pretested to know how effective they will be in treating the patient’s type of cancer.
RGCC testing may use blood or tissues and it is used to test the viability of the chemotherapy drugs in treating the cancer. It also involves genetic profiling of the cancer cell that will help the doctors decide on which treatment best suits the patient. It also checks on viability of other treatment methods that may be used alongside chemotherapy in killing the cancer.
The circulating tumor cells (CTCs) plays a major role in metastasis. Scientists have established that metastasis can never take place without circulating tumor cells. They work as the single haematological neoplasias hence are a necessity for metastasis.
Tumor initiating cells are generally known as the cancer stem cells. They refer to tumor cells that have stems and are responsible for tumor progression. The circulating tumor cells and the cancer stem cells have similar genotypic and phenotypic characteristics.
The circulating tumor cells are very effective in spreading cancer in the body and helping in its growth. It has the ability to divide asymmetrically and give rise to many cancer cells. They can also circulate as non-proliferating tumor cells hence becoming resistant to chemotherapy however they can change from this state to proliferating pluripotent progenitor cancer cells due to dissemination.
To effectively treat cancer and avoid metastasis, the circulating tumor cells and the cancer stem cells needs to be targeted and eliminated. Treatment that is not strategic in targeting the circulating tumor cells and cancer stem cells may not yield long term health benefits.
What information can be found by identification and analysis of CTCs
The study of the circulating tumor cells provides very valuable information in tumor growth and progression as well as an insight of the long term prognosis. It will also give information to whether a specific patient will be able to respond to the treatment to be offered. The doctors will study CTCs to find out the possibility of the cancer cell reoccurring after treatment.
The doctors are finding CTCs identification and analysis as an effective tool in the diagnosis, monitoring cancer cell progression as well as cancer treatment.
Some of the information that doctors find through the identification and analysis of the CTCs include;
v Possibility of long-term prognosis
v Avails information that helps in identifying treatment method that a patients can positively respond to treatment
v Possibility of the disease reoccurring after treatment
v Evaluation of tumor regression at the right time
Chemosensitivity is a very effective way of cancer treatment. It is more personalized to fit an individual’s condition hence offer the best treatment. Chemosensitivity of CTCs is done by exposing monocultures of enriched CTCs to the available cancer therapy agents. The reaction of the cells to the treatment is analyzed. The doctors will choose the best treatment by checking on which cancer therapy agent induced apoptosis of cultured cells by a great extent. The pathologists can also learn the resistance ability of the CTCs to the cancer therapy agent by checking on how long they maintain normal behavior even after exposure to the cancer therapy agent.
Chemosensitivity helps the doctors in giving effective cancer treatments to patients as the tumor cells ability to resist certain drugs are tested before the drugs are given to the patients. The ability of the circulating tumor cells and the cancer stem cells to be resistant to the treatment offered makes treatment of cancer very difficult and this explains why some cancer patients have to go through numerous chemotherapies. Through testing in labs the doctors will be able to know the cancer treatment that will wipe out all the Circulating cancer cells as well as the cancer stem cells.
For individualized cancer treatment to be effective, the identification and analysis of the circulating tumor cells and the cancer stem cells helps a great deal. Haphazard administering of cancer drugs without testing the CTCs and the stem cells resistance ability to the drug will not work well.
Chemosensitivity testing of the circulating tumor cells and the cancer stem cells is an effective approach to cancer treatment as the CTCs and the cancer stem cells are responsible for cancer cell formation and metastasis hence must be dealt with if the disease is to be effectively treated. It also hastens the recovery process as opposed to the cases where drugs given are rendered ineffective due to the CTCs resistance. Dr. Dalal Akoury runs a website that equips people with relevant information about cancer. Check on her website regularly to benefit from her wealth of health knowledge.