Mitochondrial plays very crucial in the body. Mitochondria are the powerhouse of the body as it is where energy is made. They are organelles that take in nutrients, break them down, and create energy rich molecules for the cell. Many of the reactions involved in cellular respiration happen in the mitochondria. Mitochondria are the working organelles that keep the cell full of energy. Different cells have different amounts of energy. While there are cells that have no mitochondrion, the muscle cells need to have lots of these mitochondria as they need lots of energy to accomplish their functions. Neurons are also important in the body and they too need good amount of mitochondria to serve their purposes, however they do not need as much mitochondria as the muscle cells. These organelles are very vital in the cells as they generate energy which is the mostly utilized by the cells therefore any dysfunction within the mitochondria can cause serious problems such as fatigue which is a common symptom of those suffering from chronic fatigue and fibromyalgia. Recently researchers have been able to establish a link between mitochondrial dysfunction and fibromyalgia. Findings of researchers are pointing at mitochondrial dysfunction as a possible cause of fibromyalgia.
Fibromyalgia is a disorder characterized by widespread muscle pain, joint stiffness, and fatigue. The condition is chronic but pain comes and goes and moves about the body. The cause of this disorder is unknown and therefore it is often misdiagnosed or unrecognized and is most of the times complicated by anxiety and mood disorders. this is a common disorder that according to the American College of Rheumatology diagnosis criteria affects about 3-5% of women, most of whom are between ages 20 and 50, but only 0.5- 1.6% of men. This disease is more common in adults than in children but it affects women more than men. The exact cause of fibromyalgia isn’t yet known but researchers have been trying to join dots and come up with explanations to support the possible causes that they have come up with. Mitochondrial dysfunction is one of the possible causes that have been stated by many researchers.
About 6 years ago, researchers showed that the muscles of fibromyalgia patients did not have adequate amounts of mitochondria. these researchers also noticed that even the shape of mitochondria in the muscle tissues of the fibromyalgia patients was irregular as compared to control subjects who were in the of the same age. However these findings were not explained and this prompted biologists from Spain known as Mario Cordero, Ph.D. and Placid Nava’s, Ph.D., to begin looking into an enzyme that is needed by the mitochondria: Co-Enzyme-Q10 (CoQ10). CoQ10 is an essential enzyme for detoxifying or neutralizing nasty waste products produced by the cells. The wastes that are produced by the cells are often reactive oxygen species since they react with and degrade anything that they come in contact with. Higher levels of reactive oxygen species have been found in patients with fibromyalgia and the higher levels tend to correspond to more pain. Just a year ago Cordero and Nava’s found that the CoQ10 content in the blood cells of fibromyalgia patients was 40 percent less than age-matched healthy control subjects. However, in the nutrient-rich liquid portion of the blood, the CoQ10 concentration for fibromyalgia patients was double that of the healthy controls. This imbalance in distribution of this enzyme has made Cordero and his team to do more research and establish the cause of this imbalance. These researchers noticed that the level of ROS was higher in fibromyalgia patients and this leads to programmed destruction of mitochondria.
When the levels of ROS are elevated it will lead to more tissue damage, nerve irritation. The imbalance in CoQ10 and loss of mitochondria could be linked to other symptoms that commonly occur in fibromyalgia. A reduction in mitochondria could lead to muscle weakness, more fatigue, and less ability to tolerate physical activities without flaring with more pain and exhaustion. This therefore means that if mitochondria can be rejuvenated then it can help in reducing the pain as well as support fibromyalgia treatment.
NAD is an abbreviation of Nicotinamide adenine dinucleotide. It is a coenzyme that is present in all living cells. The compound is a dinucleotide; this simply means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively. The NAD and the NADH are crucial in the production of energy in the mitochondria. What happens after eating is that the vitamins, minerals, carbohydrates, proteins and fats from our diet provide the building blocks to our bodies. Energy that is produced from citric acid cycle makes NAD and links it to hydrogen forming NADH which enters the electron transport chain in the mitochondria and is sparked with oxygen which breaks the nutrients to give energy through oxidation. This energy enables the heart to beat sufficiently and enable muscle contraction providing cellular energy that is required by the body cells to function. In fibromyalgia patients the level of mitochondria is low plus they are deformed. when a patient is put through an IV NAD therapy the level of NAD in the body is going to be high hence will be utilized in making energy in the mitochondria and help quell fatigue. NAD is also known to remove toxins like ROS that accumulate in the cells leading to programmed mitochondrial damage.
Finally, Here at AWAREmed we advocate for good health and wellness and proclaim freedom from chains of diseases. Dr. Dalal Akoury is an experienced integrative doctor who has been helping patients suffering from different conditions to live positively. Visit us at Myrtle Beach, South Carolina for help.