Tag Archives: Adrenal fatigue

The Relationship Between Addiction and Adrenal Fatigue

Addiction Causes Adrenal Fatigue

Addiction is a serious problem, addiction is the genesis of many health issues and it is even complicated to know that it is one of the wars that few people win. In the past addiction to drugs and other substances have been linked to myriads of diseases such as cancer, diabetes and other neurodegenerative disorders. This explains why addicts are not always on the good side of health, when a person is addicted to drugs and alcohol he will begin to feel sick, generally an addict is never in good health and that is why most of them may have certain strange behaviors such as irritability and even slurred speech. The reason for this is that when a person takes drugs that are rewarding in nature he will be compelled to increase the doses day by day so as to get the euphoric feeling they seek in drugs. Even the drugs that are used in pain management like the opiates have specified dosages beyond the patient will not only get addicted to the drug but will suffer other diseases that come with overdose of such drugs. Drugs of abuse majorly affect the neurotransmitter and this will be extended to the central nervous system (CNS) which is composed of the brain and the spinal cord. The brain is the engine that drives all the activities in the body of every human being but these drugs will interfere with chemical balances in the brain making it unable to perform normally. In some instance even the neurotransmitters that work to transmit signals so as to provoke certain necessary responses may get debilitated hence everything will be messed up. As expected when the neurotransmitters are affected and the entire nervous system is adversely altered then the proper coordination within the nervous system is tampered with and this is what causes a series of health complications.

Adrenal Fatigue

Recently researchers have shown that substance addiction may be linked to adrenal fatigue. Adrenal Fatigue refers to a stress-related condition that is suffered when the adrenal glands, hypothalamus and pituitary gland are functioning below their optimal level. Adrenal gland is the source of various neurotransmitters that are very vital in our nervous systems. These neurotransmitters include; cortisol, DHEA and epinephrine. These neurotransmitters are used to regulate your heart rate, immune system, energy storage and improve the general health and stability. When the adrenal glands have malfunctioned and fail to release these neurotransmitters in good amount then it will not be easy for any individual to have good health.  It is suspected that prolonged stress on the adrenal glands is what causes adrenal fatigue.

Some drugs of pleasure not only affect the dopamine but also the release of other neurotransmitters like adrenaline which is the fight or flight neurotransmitter. Even an addiction to caffeine does this. Ralph T. Golan, ND, in his book, Herbal Defense explains how using caffeine for prolonged periods can exhaust your adrenals:  “Caffeine forces your glands to secrete when they don’t have much left to give, and they have to keep digging deeper and deeper, making you more and more tired over time. And over the years, it takes more and more coffee to get the same result. Some people reach the point of drinking half a dozen or more cups of coffee to get the same result and it’s barely keeping them awake. That’s severe adrenal depletion.”

Role of adaptogens in addiction

Adaptogens are herbs that help in enhancing your immunity and ability to deal with stress, anxiety trauma, and even fatigue. Some adaptogens have been used as anti-aging herbs and have been found to have a capacity to rejuvenate the body and aid longevity. They also work to correct defects that the body is subjected to as a result of long term use of drugs of abuse.

Siberian Ginseng also known as Eleutherococcus senticosus root. This adaptogen is known for its ability to combat lack of appetite, correct insomnia, and improve memory. Siberian ginseng also increases mental alertness that is known to be lacking in those who have been addicted to substance use for quite a long time. This adaptogens also helps in healing nervous disorders and enhances energy. This adaptogens increases the body’s ability to adapt to metabolic stress and helps in recovery from substance abuse.

American Ginseng also known Panax quinquefolius root. American Ginseng is known to be a superior tonic herb with an immense ability to strengthen metabolism and the entire endocrine system. Like other species of Ginseng, the American ginseng also has adaptogenic properties, and is quite useful for the recovering addict. American Ginseng combines well with Siberian Ginseng and can be used together to heal an addict.

Adrenal Fatigue

Astragalus, also known as Astragalus membranaceous root. This adaptogens helps in promoting overall body function by strengthening digestion among other core benefits.  This herb can be used to help in restoring energy and balance the immune system in recovering addicts. It is good for some of the withdrawal symptoms of addiction like stress, colds and even chronic fatigue syndrome. It is also safe and be taken on a daily basis without it having negative side effects.

Tulsi, also known as Holy Basil. In the past this herb was used for treating such illnesses as stomach upsets and bronchitis. This herb has been found to be effective also in reducing stress that most addicts battle with. It has been found to reduce mental confusion that is common with most addicts using cannabis.

Here at AWAREmed Health and Wellness Resource Center we are committed to availing the best integrative approaches to treatment of diseases. We advocate for dietary as well as natural healing to diseases wherever possible. Visit as at Myrtle Beach, South Carolina where Dr. Dalal Akoury (MD) will be of help.

Addiction Causes Adrenal Fatigue



Kynurenine Tryptophan Cycle in Addiction

Kynurenine Tryptophan Cycle in Addiction

The immune system is an important part of normal body functioning. It is constantly modulating a balance between tolerance to non-harmful antigens and responsiveness to some pathogens. The process that facilitates tolerance is not known. However, recent studies show that this tolerance is due to tryptophan catabolism via the kynurenine metabolic pathway. The breakdown of tryptophan requires several enzymes which. These enzymes are found in various cells which includes those of the immune system.

Some of these enzymes involved in the breakdown of tryptophan produced through activation of the immune system. This process involves among others limitation of enzymes that are present in the dendritic cells and macrophages, 3-dioxygenase and indoleamine 2. Recent studies have shown that inhibition of these enzymes can result in the body rejecting allogeneic fetuses. This means that breakdown of tryptophan is necessary in immune tolerance aspects.

Some theories have been invented to try and explain how catabolism of tryptophan facilitates tolerance to drugs like alcohol. One such theory holds it that breakdown of tryptophan ends up suppressing proliferation of T cells by greatly reducing the supply of this amino acid that is critical in body processes. The other theory states that the down streaming of the metabolites involved in catabolism of tryptophan act as suppressors of some immune cells mainly through mechanisms of pro-apoptotic processes.

Kynurenine Tryptophan Cycle

What is tryptophan?

It is an amino acid that is required by all processes of the body for the synthesis of proteins and other body metabolic functions. Tryptophan is synthesized mainly from molecules like phosphoenolpyruvate that are present in bacteria, plants and fungi. Such organisms activate the tryptophan throughout the food chain. Animals are incapable of synthesizing this amino acid and because of this it must be taken in the diet in form of proteins which are then broken down into the respective amino acids in the digestive tract. The tryptophan that results from diet is deposited in the liver via the hepatic portal system. The protein that is not broken down in the liver enters into any of the two metabolic processes.

Because animals are incapable of synthesizing tryptophan, they must take it in the form of proteins, which are then hydrolyzed into the constituent amino acids in the digestive system. Dietary tryptophan is delivered to the liver through the hepatic portal system, and that portion which is not used for protein synthesis in the liver can then follow one of two basic metabolic fates.

In the first place, the protein that does not undergo synthesis can enter into the blood stream to later be used for synthesis of proteins and other cell functions in the body. Secondly, it can undergo degradation in the liver via a number of steps of metabolism which is basically referred to as the kynurenine pathway. Besides being a building block for proteins in the body, tryptophan also acts as the only source of substrate used for the production of important molecules in the body. Tryptophan is used in the gut and nervous system for serotonin synthesis and on the other hand pineal gland is useful in melatonin synthesis.  In case the content of niacin in the body is not enough to carry out metabolic processes, tryptophan come in to facilitate cellular cofactor synthesis and nicotinamide adenine dinucleotide (NAD +) synthesis. NAD + synthesis as research shows take place mostly in the liver.

The kynurenine pathway

The kynurenine pathway results from proteins that are not synthesized in the liver. The enzymatic reactions take place proceeding from tryptophan. The main intermediates of the metabolic system include quinolinate, 3-hydroxyanthranilate and kynurenine. A catabolic reaction is completed in the liver and this result in the total oxidation of the amino acid tryptophan and in the process carbon dioxide and adenosine triphosphate are produced.

Tryptophan metabolism and addiction

Tryptophan metabolism and addiction


The three stages that take place in the kynurenine pathway include an intial stage that involves tryptophan being broken down into kynurenine. The second stage starts from the produced kynurenine all the way to production of quinolinate. The final stage of the process involves enzymes that translate into total oxidation. The other processes that occurs within the three major processes picolinate production, kynuretic acid synthesis and synthesis of NAD +.

Most cells in the body have some of the enzymes that are involved in the kynurenine pathway. However, only hepatocytes have been shown to contain each and every enzyme that is used in every stage of the kynurenine pathway.  Since the liver is the only tissue in the body that contains all thes enzymes of the pathway, the liver then acts as the major site in which NAD + is synthesized from tryptophan. Diet and intake of certain substances like alcohol can affect the flow of metabolisms in the kynurenine pathway. For more information about this topic visit www.awaremednetwork.com. At AwareMed you will also find other health and awareness tips that will benefit you.

Kynurenine Tryptophan Cycle in Addiction

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Catecholamine Fatigue Is Worse Than Adrenal Fatigue

Beware! Catecholamine Fatigue Is Worse Than Adrenal Fatigue

What is catecholamine?

These are hormones which are made by adrenal glands. These hormones are released by the adrenal glands found on top of the kidneys and go into the blood streams when a person becomes under physical or emotional stress. Catecholamine is found in the main three forms; dopamine, norepinephrine and epinephrine (also called adrenalin).

What is the role of Catecholamine?

The role of Catecholamine can be understood by looking at the functions of the various components which form them. These compounds are dopamine, norepinephrine and epinephrine (also called adrenalin). Catecholamine especially dopamine and the norepinephrine are the principal neurotransmitters which mediates various activities or functions of the central nervous system.

The main function of catecholamine therefore is the regulation of functioning of the central nervous system. It sends signals which help the body to prepare to respond to stress or fright and adequately prepare the body to fight it.

How does catecholamine work?

When catecholamine gets into the body system via blood streams, it works by increasing the rates at which you heart beats, the blood pressure, breathing rate, the strength of your muscles, and also the mental strength. To ensure enough supply of blood to the main organs of the body (such as brain, kidneys, liver, lungs, heart etc.), it regulates the amount of blood going to the skin and intestines. This ensures that the main body organs are sufficiently supplied with blood.

What are the effects of catecholamine deficiency?

Just as we discussed earlier, catecholamine is a very important hormone. It is one of the two main neurotransmitters whereby the other is serotonin. Deficiency in catecholamine has been known for years to cause variety of diseases. The following are some of the diseases/ illnesses associated with deficiency in catecholamine:-

  • Depression or being moody – one of the effects of lowness in catecholamine which is known to be very common, is depression. This is one of the factors which make the catecholamine fatigue by far worse than that of adrenals. When a person who is addicted of a given substance and is also diagnosed with catecholamine fatigue, the problem becomes even more complicated to address. Before a successful addiction recovery program is undertaken, the problem of catecholamine fatigue needs to be first address. This is because it causes depression which makes it impossible for recovery from addiction to occur. The reason behind this difficulty is that for success in the addiction recovery to occur, your mind must be in good working condition. Depression in itself is a disease, and when adjoined with addiction it may make the recovery from addiction chances next to impossible.
  • A feel of anxiety – when a person is a victim of catecholamine fatigue or deficiency, the levels of excitement may be high. This is because the catecholamine is a component of neurotransmitter, which is the hormone responsible for regulation the brain’s reward system. This deficiency leaves the system un-regulated, and thus the levels of excitement may remain high, especially when initially triggered high. In this respect, catecholamine which supposed to regulate the levels of this excitement is low, and thus the levels of excitement remain high.
  • Insomnia may also occur – a state of sleep disorder is also very likely to occur. The principle behind it is that all the metabolic functions in our bodies are controlled from our minds and neurotransmitter plays the main role in this control. When there is a deficiency in catecholamine, it becomes very difficult for the brain to regulate the metabolic rates, which would facilitate sleep through activities such as regulation of the rate at which the heart beats.
  • Other common problems may include: – panic attacks, obesity, bulimia, anorexia, migraines, ADD/ADHD, Fibromyalgia just to mention a few.

What are the possible causes of depletion in catecholamine in the body?

There are several factors which have been attributed with causing depletion in catecholamine in our bodies. Some of these factors are:-

  • Simulants use – researches have shown that among the causers of depletion in catecholamine from our bodies is the use of stimulants. When one uses these stimulating substances, they lower the effectiveness of neurotransmitter and thereby creating resistance to the neurotransmitter.
  • Nutritional triggers – catecholamine (neurotransmitters) are made from proteins, and thus to ensure that they remain at a high level, we must take foods rich in proteins. When we take foods which are low in proteins for quite a long time. There is a likelihood of development of catecholamine deficiency. For a person who is an addict of a given food which is low in protein, catecholamine deficiency is a possibility.
  • Some medications especially SSRI, deplete catecholamine – research has shown that, administration of some SSRI medications can deplete serotonin receptors by 40 – 60%.
  • Stress – it has also been argued that stress can also contribute to the decline in the levels of catecholamine.

Why must catecholamine fatigue be addressed before addiction recovery program is embraced?

Catecholamine fatigue is more serious than the adrenal fatigue, although closely related. This is because unlike with adrenal fatigue, catecholamine fatigue is usually accompanied by depression and thus not unless it is addressed first, it becomes very difficult for the addiction recovery program to be successful.

Can catecholamine levels be restored?

CatecholamineRepletion of catecholamine is very easy. You just need to understand where it is synthesized from. Catecholamine and serotonin comes from the same source, which are the amino acids, vitamins and the minerals which are common in the foods we eat. These minerals are the ones which are converted into neurotransmitter, which catecholamine forms part. Therefore, to get your catecholamine restored into your body, you just need to eat much of the foods rich in these nutrients. Such foods may include: – bananas, pineapples, eggplants, red plum, tomatoes, walnuts, just to mention a few.

Alternatively, you can get these nutrients as supplements or seek advice from doctor for the administration of drugs rich in the nutrients.

From this discussion, we can clearly see the need for addressing catecholamine deficiency before we address the addiction recovery. Are you now thinking about where you can get help out of addiction or catecholamine fatigue? Your solution is here; call or visit us at Awaremed Resource And Wellness Center.

Beware! Catecholamine Fatigue Is Worse Than Adrenal Fatigue

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The Importance Of High Dose Vitamin C In Balancing The Adrenals

Vitamin C Plays an Important Role in Balancing Adrenals Prior To Addiction Recovery Program

High Dose Vitamin CWhat are adrenals?

They are also referred to as adrenal glands or suprarenal glands. They are small triangular glands, which are located on top of both kidneys in our bodies. These glands play a vital role in our bodies, since they are responsible for regulation of the functioning of our bodies and minds. They are part of the endocrine system, which is branded, “policemen” in our bodies.
What is the function of these adrenals in our bodies?

The reason why adrenals are regarded as very vital in our bodies is because they produce chemicals that maintain life. Death becomes the only option for a person, when the adrenals fail to work. The chemicals which are produced by the adrenals, convert what is eaten by a human being (which is useless to our bodies) into substances which are useful to our bodies. These substances are the ones which facilitate body functions such as growing, changing and provide tools necessary for repairing and rebuilding of body tissues.

Another importance of proper functioning of adrenals is that, they produce very important hormones. One of these hormones is the cortisol, which is a hormone known to regulate physical stress, mental activities, emotion etc. when the adrenal glands are not functioning well, they may lead to insufficient cortisol hormones supply and hence the person is faced with stress among other symptoms.

Is adrenal fatigue real?

This fatigue is a reality. It is a collection of symptoms which come as a result of adrenal glands functioning below the required level. This fatigue in most cases is depicted by intense stress, which can hardly be reduced by sleep. Sleep is a common problem in people with imbalance in adrenal glands. This lack of sleep unfortunately triggers fatigue.

This condition of adrenal functioning below the required level is common in drug addicts. When an addicted person becomes a victim of adrenal malfunctioning, it becomes a more serious problem to address. For any successful addiction program, there is a need to first address the problem of adrenal. The regulation of working of the adrenal should even come before the actual addiction recovery program.

What symptoms may indicate malfunctioning in adrenal?

Unlike any other symptoms, the adrenal Symptoms are sometimes very difficult to identify. The problem with the identification of these symptoms is that they may look similar to symptoms of another condition. Therefore, you may need to identify as many symptoms as possible, before you conclude that a given person is a victim of adrenal malfunction.

The following are some of the common symptoms or consequences of adrenals malfunction:-

  • Continued fall in body temperature. Since adrenals are responsible for regulation of many body functions such as regulation of body temperature, their malfunction may lead to decline in the body temperature.
  • Body weakness – another common symptom of adrenal malfunction is body becoming weak. This is sometimes related to stress, but when adrenals fail to work for long period, it becomes difficult for the person to remain off the bed for more than an hour in a day. Such a person will remain on the bed, since he/she feel his/her body totally weak.
  • In some cases, there may be un-explained hair loses.
  • Digestion failure may also occur
  • Memory loss is also a possibility
  • Feeling of frustration
  • Mental depression
  • Low blood pressure may occur
  • Excessive feeling of hunger may also be evident

Why is high dose Vitamin C important in preparation for addiction recovery?

When a person is an addict, there is likelihood that the addictive substance has caused damage on some body organs. These damages must be repaired, for the addiction recovery process to be successful. Likewise, when a person is faced with malfunction of adrenals, there is need to urgently get assistance to restore the glands to their normal functioning states. This restoration can be done medically or by use of nutrition.

The medical way of preparing body or assisting body in recovery, is sometimes not considered the best option, considering the possibility of side effects from the drugs or addiction from the drugs in the long run, leading to dependency on the drugs. Many people prefer the nutritional way of restoring the adrenals to their functional state due to a number of benefits it has over any other method. Vitamin c is an essential vitamin for balancing adrenals and thus any diet targeting to balance the adrenals should contain sufficient vitamin c.

High Dose Vitamin CThe following are some of the benefits of vitamin c, when it is used to prepare body and balance adrenals prior to addiction recovery treatment:-

  • High dose vitamin c is quickly used during stress. This factor makes it helpful when countering adrenal fatigue. The level of vitamin c is supposed to be kept high, since researches have shown that the rates of utilization of vitamin c are very high during the stressful moments, regardless of the source of stress.
  • Vitamin C has been proven to be very powerful in fighting infections and also boosting the general body immunity. Researches have shown that, when a person is a victim of adrenal fatigue, as the levels of vitamin C decline, the immune system also declines in the same manner. This means that the administration of high dose vitamin C improves the immunity of the body, as the levels of vitamin increase. For instance, “Vaslev and Komar (1998) determined that a dose of 300mg of vitamin C resulted in a more rapid recovery of a depressed T-lymphocyte”
  • Vitamin C is vital in pre-addiction recovery, as it play a key role in removing toxins from the body. When a person is addicted of a given drug, it is very likely that the person will be either stressed or depressed. The stress reduces the levels of vitamin c in our bodies, hence leaving us with insufficient vitamin c to remove toxins from our bodies. This is because chronic stress lowers the levels of glutathione, a very important substance in removing toxins from our bodies. This is why it is very important for a person who is addicted to be subjected to high dose vitamin c before the actual recovery program begins.
  • Vitamin c is very low in toxicity. This factor makes it possible for a person to take it in large quantities, improving the immunity drastically.

Are you thinking of how you can get help on balancing adrenals? Are you an addict and you are looking for a natural way of gradually recovering from the addiction? Awaremed Resource and Wellness Center is your solution. Call us today or visit us at www.awaremednetwork.com.

Vitamin C Plays an Important Role in Balancing Adrenals Prior To Addiction Recovery Program