Tag Archives: Angiogenesis

Treating Cancer – Related Thrombosis

Assessing and Treating Cancer – Related Thrombosis

Cancer – related thrombosis has been one of the leading causes of morbidity and mortality in patients. Its significance has been underscored by the fact that the condition can actually affect patients regardless of the stage at which the disease is. In this essay, we shall discuss an integrative approach that can be used to inhibit this condition in cancer patients. Basically, the approach that is used seeks to do two important things: make the tumor host terrain conducive to optimal health while being non – conducive to the growth and development of cancer cells through metastasis. Our focus shall be on different ways by which this objective can be achieved.

How cancer cells use angiogenesis to grow

The growth and development of cancer takes place through a series of complex and interrelated steps. An important thing to understand, though, is that for cancer cells to successfully grow, they have to be provided by a regular supply of oxygenated blood. This calls for a rich supply of blood vessels in the body of the patient. In general, a normal human body has an inbuilt mechanism by which new blood vessels are generated and develop for specific functions. This process, called angiogenesis, is vital for different purposes such as general healing of a wound and even during the process of embryo formation. Unfortunately, it is this processes that cancer cells make use of to achieve what they need most: blood supply. The cells literally hijack the process of angiogenesis and use it as a basis to support their growth and possible metastasis in the future.

molecules involved in clotting and cancer

The process of metastasis

It is important to note that metastasis of cancer cells occurs in several interconnected steps. First, after apparently normal cells of the body have been changed into completely tumor cells, a heavy network of capillaries is built around the cells. This process, angiogenesis, is necessary for the cells to develop and grow further. Research has indicated that cancerous cells are able to hasten the process by producing factors that promote angiogenesis. This build up in supply is necessary for the cells to get to the next stage which is invading the body cells of the host. After invading local body cells the newly develop cancer cells then undergo a process of breaking free from the original mass and spreading to other parts of the body. Cancer cells, in singular or groups, break away from the original mass and get spread through the supply system of the body. Although some are destroyed, there is always a good amount of cells which survive. It is the surviving cells that move across the body, find a new organ or tissue upon which to base their growth and begin the process of getting a new supply of blood afresh. This sets a new foundation for the process to repeat itself.

The role of Angiogenesis

It is the role that angiogenesis plays in this process that has stimulated a lot of research in use of therapies that inhibit it. The thinking behind this approach is that once the process has been inhibited, cancer cells will be deprived of their most vital resource: blood supply thus being condemned to an early death. The crux of the matter, however, is that with the use of anti – angiogenesis drugs comes the risk of cancer – related thrombosis. The problem is complicated further when one considers that different types of conventional cancer therapies have also been known to increase the possibility of the occurrence of cancer – related thrombosis in cancer patients.

Integrative approach to treat cancer – related thrombosis

This, therefore, calls for an integrative approach to treatment that arrests the process of metastasis while at the same time promoting optimal growth and reducing the possibility of cancer – related thrombosis. There are several things that such an approach is made up of which include the use of botanicals, botanical compounds, enzymes, nutritionals, diet and life-style changes.

  • Lifestyle changes

It is important for cancer patients to carefully observe their lifestyles. Leading a healthy and active lifestyle plays a key role in reducing the possibility of one developing any of the different forms of cancer – related thrombosis. Furthermore, by using a diet that contains foods rich in different minerals such as vitamin E, omega – 3 fatty acids and polyphenol, it has been established that one would be reducing the possibility of such an occurrence.

  • Use of botanicals

There are several different botanicals that have been used to reduce angiogenesis and, by extension, occurrence of cancer – related thrombosis in patients. For instance, some herbs used in Traditional Chinese Medicine have been found to exhibit these properties. Also, green tea, which contains a relatively high proportion of polyphenols, can be a useful product. However, the bulk of research on this score has been on botanicals such as Chinese wormwood Curcumin. The research has been focused on how particular agents found in these plants can be used effectively to counter the effects of particular cancer therapies in promoting the process of angiogenesis upon which metastasis and cancer – related thrombosis are based.

For years, our focus here at AWAREmed, has been to use the best available practices to ensure that our patients are free from the possibility of cancer – related thrombosis. To achieve this, we use a sound approach that is completely personalized to the needs of our clients, thus guaranteeing them the best services in integrative approach to cancer treatment.

Assessing and Treating Cancer – Related Thrombosis

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Angiogenesis Inhibitors and Cancer

Angiogenesis Inhibitors Play A Great Role In Cancer Treatment

AngiogenesisMetastatic static cancer is a fear of every cancer patient. Metastasis makes it hard for cancer to be treated. However cancer cannot metastasize without angiogenesis which is the sprouting of new blood vessels. The oncologists can best avoid metastasis by avoiding angiogenesis which is only achieved by use of angiogenesis inhibitors.

Angiogenesis defined

Angiogenesis is a process through which blood vessels are formed. Angiogenesis occurs naturally during the growth and development of children. The mother’s womb has to form new blood vessels that are important in the development of the infant. This is a crucial process in the foetus. However in adults this process happens less often and may happen during wound healing. In women it happens during the menstruation cycle. When this formation of new blood vessels is induced by tumor, it is referred to as tumor angiogenesis. This happens when the tumors release molecules that signal the surrounding tissues. It is this signaling that activates genes that make proteins to initiate growth of new blood vessels. These new blood vessels penetrate into the cancerous cells and help them grow by supplying them with the needed nutrients and removing wastes out of them hence creating an environment that favors their growth and metastasis.

Without angiogenesis tumors cannot grow and metastasize, it is therefore a necessity without which the cancerous cells will become inactive and will even die. When the new blood vessels have been formed it become hard for the cancer to be treated. The cancer patient will have to endure pain as the tumors will be growing at a faster rate since they have adequate nutrient supplies which they receive though these newly formed blood vessels therefore they can be controlled when these nutrient supplies are cut and that is what angiogenesis inhibitors does.

This discovery that cancer cells depend on angiogenesis to grow and metastasize has led to development of many cancer treatments that target angiogenesis. These therapies can be very effective in fighting this disease since it doesn’t affect the healthy body cells. Moreover if angiogenesis can be inhibited then all cancers can be controlled since it is a necessity for growth of tumors in all cancers. When angiogenesis is inhibited the cancer cells are denied of their supplies and they will automatically die of starvation.

Copper is a necessity for Angiogenesis

Copper is a trace element the needs to highly regulated as any slight homeostatic copper disruptions may result in serious health complications such as the Wilson’s disease. Copper is necessity for angiogenesis. Without copper angiogenesis cannot take place. It is therefore evident that Copper fuels cancer tumor growth and metastasis. Angiogenetic inhibitors can be used to curb this situation. Tetrathiomolybdate (TM) is effective in copper chelation.  Researchers have proved that TM forms a stable tripartite complex with copper and protein. When given with food, it chelates food copper with food protein and inhibits absorption of copper in the bloodstream. There is endogenous secretion of copper in saliva and gastric secretions associated with food intake, and this copper is also chelated by TM when it is taken with meals, thereby preventing copper re-absorption.

Medical researchers have done test on the effectiveness of the tetrathiomolybdate (TM) on mice that were injected with cancer cells and left for a week for angiogenesis to begin. After the new blood vessels had been formed the mice was injected tetrathiomolybdate (TM). The angiogenesis stopped and the tumor growth stopped. However from researches that had been done in the past it was concluded that tetrathiomolybdate (TM) has a unique action on the copper that fuels angiogenesis and retarded tumor growth with minimal side effects. When cancer patients are given TM with food they get a negative copper balance which is not good angiogenesis. The copper that is bound by TM cannot do any meaningful biological activity as it cannot be absorbed by cells and is excreted in the urine having been cleared by bile hence tamed.

Normally, the level of copper that is needed for angiogenesis is much higher as compared to the amount of copper that is needed for cellular activities that are dependent on cancer like cytochrome function and heme synthesis. Cancer therapy that are based on anti-copper may work well as the copper needed for cellular activities will be retained even when TM is used to as an anti-copper angiogenic agent.

Low molecular weight heparins inhibits metastasis

AngiogenesisIt has also been found out that Low molecular weight heparins helps in improving the cancer patient’s chances of survival as it inhibits metastasis. The low molecular weight heparins are able to inhibit metastasis by preventing cancer cell triggered destruction of the endothelial glycocalyx. In experimental animal models and clinical tests; it was found that the low molecular weight heparins protects against cancer progression and metastasis. The scientists say this is possible as the low molecular weight inhibits metastasis interfering with the cancer cell binding on the platelets. Cancer cell needs to attach themselves to the platelets to move to other parts of the body. Low molecular weight heparins also inhibit metastasis through binding of heparanase or hyaluronidase thereby protecting the vascular endothelium from invasion by the cancer cells.
Dr. Dalal Akoury (MD) is an experienced integrative cancer doctor that has helped many cancer patients in their fight against the disease. She has worked hard not only in treating the disease but also in availing informational support to cancer patients at Awaremed which has become a place called home for many cancer patients. Call on her now and get help on cancer.

Angiogenesis Inhibitors Play A Great Role In Cancer Treatment

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Angiogenesis and Metastasis

 The Role of Angiogenesis Inhibitors In Integrative Cancer Care
Cancer patients always have a fear that their cancer may become metastatic. If it becomes metastatic it becomes a problem to treat and may cause lots of damage to the healthy cells in the patient’s body. Metastastasis however cannot happen without angiogenesis. Therefore if the cancer doctors find a way of avoiding angiogenesis then it can be easier to avoid metastatic cancer. One of the known characteristics of cancerous cells is that they divide rapidly and their growth is uncontrolled, this is a major challenge as the danger increases with how well they are well spread in the body. The best way to control the spread of cancer is to control angiogenesis by the aid of angiogenesis inhibitors.

What is angiogenesis?

Angiogenesis is the formation of new blood vessels. This is a natural process that occurs majorly during growth and development of children. The mother’s womb has to form new blood vessels that are important in the development of the infant. This is a crucial process and is known as vascologeneis. However this process happens less often in adults and may happen during wound healing. In women it happens during the menstruation cycle. When this formation of new blood vessels is induced by tumor, it is referred to as tumor angiogenesis. This happens when the tumors release molecules that signal the surrounding tissues. It is this signaling that activates genes that make proteins to initiate growth of new blood vessels. These new blood vessels penetrate into the cancerous cells and help them grow by supplying them with the needed nutrients and removing wastes out of them hence creating an environment that favors their growth and metastasis.

For tumors to grow and metastasize, angiogenesis is a necessity without which the cancerous cells will become inactive and may even die. The network of newly formed blood vessels become very dangerous to the cancer patient as they enhance the growth of the cancerous cells, spreading to other parts of the body and inflicting pain. For this situation to be controlled there is need to cut the nutrient and oxygen supply to these cancerous cells.

Being that cancer cells depend on angiogenesis to grow and metastasize, cancer  therapies that target  angiogenesis can potentially help in treating cancer. Angiogenesis is necessary for growth and metastasis of all cancer cells irrespective of the type of cancer. Cancer treatments that target angiogenesis will definitely aid in treatment of all cancers. The basis of therapies that target angiogenesis is that if angiogenesis can be stopped then the cancerous cells will be killed as they will not access the necessary supplies hence will starve to death.

Copper and Angiogenesis

Copper is a trace element the needs to highly regulated as any slight homeostatic copper disruptions may result in serious health complications such as the Wilson’s disease. Copper is also known to be necessary for angiogenesis. Without copper angiogenesis cannot take place. Copper therefore fuels cancer tumor growth and metastasis. Anti-angiogenic therapies can be used to curb this situation. tetrathiomolybdate (TM) is effective in copper chelation.  Researchers have proved that TM forms a stable tripartite complex with copper and protein. If given with food, it chelates food copper with food protein and prevents absorption of copper in the bloodstream. There is endogenous secretion of copper in saliva and gastric secretions associated with food intake, and this copper is also chelated by TM when it is taken with meals, thereby preventing copper re-absorption.

Researchers have tested the effects of the tetrathiomolybdate (TM) on mice that were injected with cancer cells and left for a week for angiogenesis to begin. After the new blood vessels had been formed the mice was injected tetrathiomolybdate (TM). The angiogenesis stopped and the tumor growth stopped. Tetrathiomolybdate (TM) is targeted by many researchers who want to verify if it can be used as a cancer treatment. However from researches that had been done in the past it was concluded that tetrathiomolybdate (TM) has a unique action on the copper that fuels angiogenesis and retarded tumor growth with little side effects. If cancer patients are given TM with food their copper balance become negative which does not support angiogenesis. The copper that is bound by TM cannot do any meaningful biological activity as it cannot be absorbed by cells and is excreted in the urine having been cleared by bile.

Typically the level of cancer that is needed for angiogenesis is much higher as compared to the amount of copper that is needed for cellular activities that are dependent on cancer like cytochrome function and heme synthesis. Cancer therapy that are based on anti-copper may work well as the copper needed for cellular activities will be retained even when TM is used to as an anti-copper angiogenic agent.

Low molecular weight heparins

Researchers have also found out that Low molecular weight heparins helps in improving the cancer patient’s chances of survival as it inhibits metastasis. The low molecular weight heparins are said to curb metastasis by preventing cancer cell triggered destruction of the endothelial glycocalyx. In experimental animal models and clinical tests; it was found that the low molecular weight heparins protects against cancer progression and metastasis. This is said by the scientists is possible as the low molecular weight inhibits metastasis interfering with the cancer cell binding on the platelets. Cancer cell needs to attach themselves to the platelets to move to other parts of the body. Low molecular weight heparins also inhibit metastasis through binding of heparanase or hyaluronidase thereby protecting the vascular endothelium from invasion by the cancer cells.

Dr. Dalal Akoury (MD) is an expert in integrative cancer treatment and can avail you the best advice to help you cure or better yet prevent cancer. You can always call her for consultations.

 The Role of Angiogenesis Inhibitors In Integrative Cancer Care

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