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Mitochondrial restorations and weight loss

Mitochondrial restorations

Mitochondrial restorations and weight loss and benefits of kicking out obesity by being physically active

Mitochondrial restorations and weight loss: Mitochondrial dysfunction

The role of your metabolism is to take the oxygen we breathe and the food we eat and process it to make energy, the fuel for life. (The fuel for your car is called gas. The fuel for your body is called ATP and it is produced from the combustion of food and oxygen.) When they are not working properly, you suffer all the symptoms of low energy: fatigue, memory loss, pain, rapid aging, and more. Along the way, many things can go wrong that may impede your metabolism, make it run less efficiently, or practically shut it down. Fatigue is the most common symptom of poorly functioning mitochondria. We need to keep them in top shape. Therefore mitochondrial restorations will be essential even as we move close to our old age and that explains why we poop out as we age because we have constantly insulted and injured our mitochondria.

Did you know that we have over 100,000 trillion of these powerhouses in our body, and each one contains 17,000 little assembly lines for making ATP, our major fuel? They use over ninety percent of the oxygen we breathe. They take up forty percent of the space inside the heart cells. The only problem is they are very sensitive to damage. And the injury is from uncontrolled oxidative stress, which results from toxic insults, infections, allergens, stress, and just eating too much poor quality food.

Mitochondrial restorations and weight loss: Exercise and the mitochondria

  • Getting rid of toxins in the body will give you more energy. So here’s another reason to exercise: Exercise accelerates the detoxification process.
  • Exercise pushes the blood to circulate more efficiently through the body, allowing nutrients to move easily to reach all the organs and muscles.
  • Exercise helps lymph fluids circulate through the body, which removes toxins and other harmful materials. When you exercise, you naturally take in more oxygen; to make room for the added oxygen, your cells kick out toxins that are taking up space. When you exercise properly, your build up a sweat and toxins are released through the pores of the skin.
  • Playing at anaerobic levels is a great way to get in peak shape. It doesn’t do anything for longevity, or probably for overall health, but it’s great for vim, vigor and pure fitness.
  • Regular exercise is one of the most important things you can do for health. Participation in physical activity improves several body functions. These include: weight control, decreased the risk of cardiovascular disease, decreased risk of diabetes, reduced risk of cancer, improved strength of bones and muscle, enhanced emotional status, decreases the natural degenerative changes that come with aging, and increases your chances to live longer.
  • That said, being consistently active can actually cause degeneration. Rest and recovery periods are essential as these periods allow the body to repair and rebuild itself.

Finally, there are lots of benefits in being physically active. Doctor Dalal Akoury MD, President, and founder of AWAREmed health and wellness resource center reiterated that this is a virtue. Nonetheless, we’ve to distinguish between consistent exercising which can lead to overuse injury and regular exercising. You must be sure to discern between consistently exercising and regular exercise and for more professional input over this, you can schedule an appointment with her by calling her now.

Mitochondrial restorations and weight loss: Mitochondrial dysfunction

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IV NAD in Cancer Treatment

IV NAD as an Alternative cancer treatment

What is NAD?

IV NADNicotinamide Adenamide Dinucleotide (NAD) is an important molecule in the body of humans that is related to the process of production of energy required for all life activities. Basically, the food that we eat is usually broken down through a complex biochemical process to produce this molecule. The NAD molecule that is produced is then used to transport hydrogen at the cellular level. The combination of hydrogen that is carried by this molecule with oxygen within the mitochondria of the cell produces energy and water as byproducts of the reaction. The energy, which is produced in the form of a molecule called ATP, is what drives the processes of life in the body of a normal human being.

For healthy individuals, the importance of NAD cannot be overemphasized. First, availability of the molecule in sufficient amounts is necessary for one to experience a feeling of overall physical energy. Further, having sufficient amounts of NAD in the body is associated with good mental health, increased libido and overall good health. All these are positive attributes that make this molecule an important determinant of how healthy a person is at any given time. The reverse is true; deficiency of NAD in the body often leads to prolonged fatigue and other related illnesses.

Relationship between NAD and Cancer

There is a very complex relationship between the NAD molecule and different types of cancer. To begin with, the molecule is a byproduct of a complicated biochemical process known as the citric acid cycle in the cells. At the start of the citric acid cycle is vitamin B3, an important nutrient that is derived from good nutrition. Therefore, vitamin B3 is an important precursor for the production of NAD in the body.

One of the most important types of vitamin B is Niacin. This is a chemical that is produced in the body of a healthy individual and its function is to produce special enzymes that are required for the proper production and utilization of NAD. The enzymes are also useful in that they ensure that the Kreb’s cycle within the cells progresses without any major interruption. In the event that the cycle is interrupted as a result of lack of coenzymes, which can be traced back to insufficient niacin in the body, the cells of the body get exposed to the possibility of development of cancer.

The link between deficiency of NAD and possible development of cancer can best be understood when one considers what happens to the cells of the body when the normal Kreb’s cycle is interrupted with. Under such conditions, there is increased production of lactic acid and fermentation as the body cells seek to get a new source of energy. With increased fermentation, there is a rise in the level of lactic acid within the cells. It is such anaerobic conditions that precipitate the conversion of somatids into fungi – like microorganisms that have been found to play a key role in inducing changes in otherwise normal and healthy body cells into toxic and cancerous ones.

Therefore, lack of niacin leads to deficiency in NAD which in turn causes a decline in the amount of important enzymes. The end result is that the cell environment becomes toxic, characterized by an increase in lactic acid, conditions that ultimately lead to cancer development.

How IV NAD works as an alternative cancer treatment

There are several specific ways in which IV NAD treatment works as a component of an alternative cancer treatment regimen. What one needs to know, however, is that when administered intravenously, the treatment is quite effective because then NAD is transported to the brain of patient. Since this is where the receptors of the molecule are located, intravenous administration of this treatment produces intense and long standing results in patients. It is here that the effects of the molecule are felt before being replicated in the other parts of the body.

One way in which IV NAD treatment can be useful for cancer patients as part of the alternative treatment therapy being used lies in its characteristic as a strong detoxification agent. Basically, NAD has been known to rid the cells of all manner of toxins that accumulate over the course of time, particularly under conditions of a debilitating condition like cancer. Therefore, when administered to cancer patients, IV NAD treatment enhances the overall health of the patient by cleansing the cells of the body of all manner of toxins.

Another way in which this form of treatment can be useful as an alternative cancer treatment technique lies in its ability to boost the effectiveness of other forms of treatment that are in use. This treatment is effective in enhancing the ability of pharmacological drugs being used as treatment to kill cancerous cells in the body of a patient. The exact mechanism by which the treatment enhances the cancer – killing ability of chemotherapy while preserving normal body cells is a topic of research.

IV NADTherefore, common understanding is that niacin itself shown anti- cancer properties and when used as part of an IV NAD treatment in cancer patients, is able to enhance the effectiveness of other standard therapies being used.

IV NAD is offered at AWAREmed Health and Wellness Resource Center as part of alternative cancer treatment therapy. Dr. Dalal Akoury has won accolades in the practice of alternative treatment for cancer. You can pay her a visit for this service as well as other natural methods of overcoming NAD deficiency in the body. We are located in Myrtle Beach, South Carolina.

IV NAD as an Alternative cancer treatment

 

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DCA As a Glycolitic Inhibitor

DCA  As a Glycolitic Inhibitor Helps In Fighting Cancer

DCAThe oncologist will tell you that finding a treatment that is effective in killing the cancer cells while safe on the healthy body cells was the biggest problem in the field of oncology. The cancerous cells just as much as the healthy cells need nutrients to continue living.  The oncologists plus other medical researchers have noted that the best way to treat cancer without affecting the healthy body cells is to deny them the nutrients supplies so that they can be starved to death. The cancer cells and the body cells require glucose from which they can make the ATP energy that they need to survive on. This made it hard to deny the cancer cells their nutrient supplies while leaving the healthy body cells nutrient supply unaffected. But this was in the past. Cancer researchers have found some existing differences between the survival mechanisms of the cancerous cells and the healthy body cells. Otto Warburg discovered that the cancerous cells depended entirely on the glucose to survive without which it could not live while the healthy body cells could make other sources of energy and continue living even when the sugar sources of energy were withdrawn. This discovery has led to more selective killing of the cancer cells without affecting the living body cells. The cancerous cells undergo increased glycolysis and rely on this pathway for generation of ATP energy as their sole source of energy for growth and survival but the healthy body cells are flexible to switch to other sources like fats.

Since the discovery by Warburg, oncologists have come up with different cancer therapies to help in killing the cancer cells effectively without hurting the healthy body cells. Overdependence of the cancer cell on the glycolitic pathway for generation of ATP energy as the sole source of survival has provided a great loophole through which the cancer cells can be selectively killed without affecting any other healthy cell by inhibiting glycolysis. To do this, glycolitic inhibitors must be used in order to weaken the cancer cells by blocking their nutrient supplies which is an anticancer itself thereby killing the cancer cells more effectively.

Cancer cells are characterized by increased glycolysis therefore when glycolitic inhibitors are used the cancer cells have no other ways of survival therefore they will die out of starvation. This approach has also been applauded in killing of cancer cells with mitochondrial defects that have become resistant to chemotherapy and radiation therapy drugs.

It may not be easy to understand the molecular and biochemical mechanisms that lead to increased aerobic glycolysis in the cancer cells, the metabolic repercussions of this increased glycolysis is very clear. The malignant cells become dependent or other addicted to the glycolysis pathway as the sole source of ATP energy. Researchers opine that the increased glycolysis in cancer cells may be caused by such factors as; hypoxia, oncogenic signals as well as mitochondrial dysfunction.

It is a known fact that the cancer cells need more energy to survive than the healthy cells. In glycolysis the ATP produced per glucose are only 2 which means the cancerous cells must use lots of glucose to survive unlike in the oxidative phosphorylation which generates more ATP energy per glucose the . Here 36 ATP are produced per glucose therefore small amount of glucose is needed for survival. So without glycolitic pathways the cancer cells are doomed.

In case of is glycolytic inhibition the healthy body cells will be able to adapt to other metabolic pathways to generate the ATP energy through the TCA cycle and oxidative phosphorylation in the mitochondria. The cancer cells however cannot adapt to other sources of ATP hence will die as they will not be able to live without another source of ATP energy. The healthy body cells will be able to adapt to new sources of energy like fatty acids and amino acids to produce metabolic intermediates channeled to the TCA cycle for ATP production through respiration. Glycolysis inhibition is therefore a clever way of killing the cancer cells without harm on the healthy body cells.

DCA is an effective glycolytic inhibitor

DCA works in very interesting ways in inhibiting glycolysis. It only leaves one option left for cancer cells to survive on- depending on other pathways as opposed to glycolysis. The cancer cells cannot do that hence they are killed. The healthy body cells can adapt to metabolic changes unlike the cancerous cells. The first way through which the body cells get energy is through glucose oxidation which happens in the mitochondria of every cell in the body and requires oxygen. Glucose respiration is the mostly utilized form of metabolism in the healthy cells. However in absence of oxygen the cells turn to glycolysis which takes place in the cell cytoplasm for energy generation. Glycolysis does not avail adequate ATP energy for normal cells; however it is the best for cancer cells. Glycolysis depends on sugar. This gives the healthy cell advantage as they have a backup plan in case the oxygen supply is interrupted. However to oxidize glucose there must be pyruvate. Pyruvate entry into the mitochondria is inhibited by an enzyme known as pyruvate dehydrogenase kinase (PDK). In case the PDK is strong then it will limit the transportation of pyruvate into the mitochondria and the healthy cells will have to depend on glycolysis even in presence of oxygen but incase its weak the pyruvate will be transported with ease to mitochondria even when the oxygen is low.

DCACancer cells have the most active PDK than the healthy cells and they are adapted to glycolysis. When PDK is weak then the cancer cells are disadvantaged and this is what the DCA does. It weakens PDK forcing the cancer cells to rely on glucose oxidation which does not favor them. Hence they will starve and die.

Dr. Dalal Akoury (MD) is an experienced integrative cancer doctor that has helped many cancer patients in their fight against the disease. She has worked hard not only in treating the disease but also in availing informational support to cancer patients at Awaremed which has become a place called home for many cancer patients. Call on her now and get help on cancer.

DCA As a Glycolitic Inhibitor Helps In Fighting Cancer

 

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Giving Your Mitochondrial Health a boost by IV NAD

Restoring Mitochondrial Health by IV NAD

What are mitochondria?

They are membrane bound organelles which are found in most of the cells (eukaryotic cells) that make up living things. They are also sometimes termed to as the powerhouses.

Why are mitochondria vital in our bodies?

Mitochondrial HealthAs we have just mentioned, mitochondria are also referred to as powerhouse due to the functions that they do in our bodies. Their main work is to generate the energy that our body cells require in order to execute their jobs. One of such cells which need a lot of energy is the brain cells. The brain cells are responsible for the communication to all the other parts of the body and thus these mitochondria must be transported along the cells.

Mitochondria generate chemical energy similarly to the one we normally get from batteries. This energy which is generated by the mitochondria in the form of chemical is referred to as Adenosine Triphosphate or simply ATP. This is an energy currency that every ling thing cell can use and this is what makes it possible for us to be kept alive.

What are mitochondrial diseases?

These are diseases which result from the failure of mitochondria. As we already know, mitochondria are responsible for supplying energy to the cells. Mitochondria themselves are present in all the cells except in the red blood cells. They produce about 90 of the energy that the cells use. In the case when the mitochondria fails to work, then the energy that the cells get decline and consequently cell injury or even cell death follow. If the process occurs all over the body, then the whole system fails and the life of the person in which it is happening becomes threatened.

These mitochondrial diseases commonly cause damage on critical organs such as the brain, heart, skeletal muscles, kidney and sometimes the respiratory system.

Symptoms of a mitochondrial disease watch out for

The symptoms of a mitochondrial disease vary depending with the cells that are affected. Generally they may include the following:-

  • There may be loss in motor control
  • Muscle weakness and pain may also be another symptom
  • Visual or hearing impairment, especially if their system cells are the ones affected.
  • Gastro-intestinal disorders & Swallowing difficulties may be evident when the respiratory cells are affected.
  • Another symptom of mitochondrial disease is poor growth, since for growth to occur, cell multiplication must occur and it is a process that requires a lot of energy.
  • The victim may also become diabetic
  • Cardiac disease
  • Liver disease
  • Respiratory infection
  • Seizure among many other symptoms.

Which principle is used in mitochondrial restoration?

Mitochondrial HealthMitochondrial restoration is a natural process that seeks to restore the various body organs which have been previously cellularly affected to their normal working state. The mitochondrial restoration targets the organs that have been affected by the decline in energy supply and hence whose functional capacity has been also been affected and then restores its functional state.

Mitochondrial treatment involves measures that restore cells to their normal working condition by ensuring they get the energy necessary for them to function. These measures involve ensuring that there are sufficient mitochondria in the body and they are working correctly. Therefore, the treatment seeks to eliminate the cause of mitochondrial failure which had previously occurred.

Why is IV NAD preferred in mitochondrial restoration treatment?

What is NAD? NAD refers to Nicotinamide adenine Dinucleotide, which is a metabolic co-enzyme responsible for every aspect of life. There are basically two classes of these co-enzymes, digestive and metabolic enzymes. NAD treatment bases on the metabolic enzyme, as this enzymes are responsible for restructuring, repair and remodeling of the cells. The metabolic enzyme provide an advantage in that they operate in every cell, every organ and every cell. NAD is essential in the production of ATP, which is the basic energy molecule in our bodies.

Advantage of IV NAD therapy in mitochondrial health restoration

As we have seen, mitochondria are very important since they are responsible for the production of energy that the cells use. When the cells do not get enough energy due to failure in mitochondria, this is a death threatening disease since it may cause all the cells to fail in their function and consequently failure in the entire systems which may pose the patient to death.

If the situation of energy deficiency occurs as a result of mitochondrial failure, this situation needs to be addressed as soon as possible. Prescription can be given to the patient in response to the situation, but this method has limitations. Some of the medications that are administered to mitochondrial failure patient are known to be habit forming and may cause dependency. This makes the patient rely on the medication on daily life and in case of withdrawal; withdrawal symptoms and craving for the drugs may follow.

IV NAD therapy is a treatment that is natural and is based on the principle that, “body has ability to heal on itself as long as the necessary conditions are maintained.” This means that even after the therapy is administered to the patient, there cannot be addiction to the drug. Another advantage is that the therapy generally contributes to the well-being of a person by ensuring the mitochondria are working correctly as well as the NAD co-enzymes.

Restoring Mitochondrial Health by IV NAD

 

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Glycolysis Inhibitors Help in Fighting Cancer

 

The Role of Glycolysis Inhibitors In Fighting Cancer

The best way of killing cancer cells is to starve them. This is the safest way of killing cancer cell as the normal healthy cells are not affected by this way of killing the cancerous cells. In the past it was a big problem finding a way of killing the cancerous cells without affecting the healthy body cells. This is because all the cancer cells as well as the healthy body cells depend on glucose as their energy source that they need to survive. However very many researchers have done work on the subject of cancer cell metabolism and the discovery by Otto Warburg that the cancer cells depended entirely on glucose for source of energy unlike the healthy body cells that can adapt to other sources of energy like fats helps a lot in selective killing of cancer cells without hurting the healthy body cells. The cancerous cells undergo increased glycolysis and rely on this pathway for generation of ATP energy as their sole source of energy for growth and survival.

Basing arguments on the Warburg effect, doctors have come up with different cancer therapies to help in killing the cancer cells effectively without hurting the healthy body cells. The cancer cell overdependence on the glycolitic pathway for generation of ATP energy as the sole source of survival has provided a great loophole through which the cancer cells can be selectively killed without affecting any other healthy cell by inhibiting glycolysis.

There are Glycolytic inhibitors that can be used in maiming the cancer cells by denying them their source of livelihood. By inhibiting glycolysis they exert an anticancer effect on the cancer cells hence help in killing the cancer cells.

Glycolytic inhibitors can be used mostly in fighting cancer cells that have mitochondrial defects or in hypoxic conditions. These cells often become resistant to conventional medication such as chemotherapy or radiation therapy. However increased glycolysis is a common characteristic of all tumor cells and glycolysis inhibition can be used in wide range in treating cancer patients.

Though it may be difficult to understand the molecular and biochemical mechanisms that lead to increased aerobic glycolysis in the cancer cells, the metabolic repercussions of this increased glycolysis is very clear. The malignant cells become dependent or other addicted to the glycolysis pathway as the sole source of ATP energy. Researchers opine that the increased glycolysis in cancer cells may be caused by such factors as; hypoxia, oncogenic signals as well as mitochondrial dysfunction.

The cancer cells have to access a reliable supply of glucose in order to live. Unlike oxidative phosphorylation which generates more ATP energy per glucose the ATP generation of ATP through glycolysis is too little. Typically oxidative phosphorylation produces 36 ATP per glucose while glycolysis produces 2 ATP per glucose. This therefore forces the cancer cells to eat more glucose for effective metabolism as well as to accomplish other activities. The cancer cells therefore need to maintain glycolitic activities in order to grow and live on.

This metabolic characteristic of the cancer cells has availed a better way of killing cancer cells. Researchers have now proved that by inhibiting glycolysis the cancer cell will stop production of the ATP energy that they depend on and so they will die out of starvation.

When there is glycolysis inhibition the normal body cells will be able to adapt to other metabolic pathways to generate the ATP energy through the TCA cycle and oxidative phosphorylation in the mitochondria. The cancer cells however cannot adapt to other sources of ATP as they have defects hence will die as they will not be able to live without another source of ATP energy. The healthy body cells will be able to adapt to new sources of energy like fatty acids and amino acids to produce metabolic intermediates channeled to the TCA cycle for ATP production through respiration. Glycolysis inhibition is therefore a clever way of killing the cancer cells without harm on the healthy body cells.

DCA as a Glycolysis inhibitor

The way DCA works as a glycolysis inhibitor is very interesting; it forces the cancer cells to generate ATP through glucose oxidation but the cancer cells are not able to do this and they get starved and die. The healthy body cells can adapt to metabolic changes unlike the cancerous cells. The first way through which the body cells get energy is through glucose oxidation which happens in the mitochondria of every cell in the body and requires oxygen. Glucose respiration is the mostly utilized form of metabolism in the healthy cells. However in absence of oxygen the cells turn to glycolysis which takes place in the cell cytoplasm for energy generation. Glycolysis does not avail adequate ATP energy for normal cells; however it is the best for cancer cells. Glycolysis depends on sugar. This gives the healthy cell advantage as they have a backup plan in case the oxygen supply is interrupted. However to oxidize glucose there must be pyruvate. Pyruvate entry into the mitochondria is inhibited by an enzyme known as pyruvate dehydrogenase kinase (PDK). In case the PDK is strong then it will limit the transportation of pyruvate into the mitochondria and the healthy cells will have to depend on glycolysis even in presence of oxygen but incase its weak the pyruvate will be transported with ease to mitochondria even when the oxygen is low.

Cancer cells have the most active PDK than the healthy cells and they are adapted to glycolysis. When PDK is weak then the cancer cells are disadvantaged and this is what the DCA does. It weakens PDK forcing the cancer cells to rely on glucose oxidation which does not favor them. Hence they will starve and die.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has seen very many cancer patients journey to victory in their fight against cancer. She is available for consultations. Just call her now and begin your journey to victory against cancer.

The Role of Glycolysis Inhibitors In Fighting Cancer

 

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