Tag Archives: autologous stem cell

stem cell therapy

A better alternative than Arthritis Surgery

One of the reasons stem cell therapy holds much hope in the future of medicine is the fact that it is believed that in some years to come, it would be able to manufacture normal adult tissue to replace the damaged and old ones.

Use of embryonic stem cells remains debatable for several reasons. Among them are ethical issues that scientist haven’t been able to address properly. Among the successes of this project includes the use of autologous stem cells which are obtained directly from the patient.

Stem cells have proven to be quite useful in regenerative medicine. However, several scientists are still trying to figure out if it can work for cases related to soft tissue complications such as cartilage.

Autologous stem cells can be obtained from the bone marrow and fat from which after they are removed, they are concentrated. Some institutions go ahead and manufacture them outside the human body using several growth activators, and that is one of the reasons, they are having a hard time agreeing with the FDA.

Some centers have a lot of growth factors that don’t require processing these cells outside the body. They also don’t need to inject these cells into the location of the damage such as the joint. Instead, they’ll involve several procedures that combine the use of diagnostic ultrasound, magnetic resonance imaging and lastly, x-rays.

One of the reasons scientists advise the area of injury is that the original purpose of the Autologous stem cells incorporates inducing acute injury that is performed using several tools. These tools activate inflammation in the area that is affected.


stem cell therapy

Stem cells combined with growth factors are directly injected to the area affected, and the process of healing begins immediately.

If it is both the scientists and those who don’t like the procedure due to ethical issues can’t arrive at an agreement about the application of regenerative medicine which has been proven to treat damaged cartilage, then there is a high chance that the joint replacement therapy might take time.

Several issues haven’t been addressed. Here are some of them.

  • Will autologous stem cells solve the problem?
  • Must they be incubated outside the human body?
  • Will the ASCs be able to survive the environment that they will be placed in/
  • What more can it do to your body other than treating the targeted disease?

Unless the scientists can give those who oppose the procedure an answer, it will be hard for the world to allow them to continue with their research. One of the main issue here result from the fact that stem cells, unlike any other body cell, can multiply to form other body cells which make it a unique one, but also a risky one. However, scientists are doing what they can to find the answers that will inform the public of its importance.


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stem cells

Stem cell for regrowing cartilage

Approximately 20 to 40 million Americans suffer Osteoarthritis which is also one of the most popular forms of arthritis. This complication involves an early-stage deterioration of articular cartilage. Cartilage is simply a connective tissue without nerves or blood vessels.

One of the symptoms is the pain that results from inflammation caused by the production of destructive enzymes and can also be influenced by biomechanics.

In the previous year’s treatment of osteoarthritis used to be symptomatic that involved injections of glucocorticoids in the joints, oral ingestion of inflammatory drugs or injection of visco-supplements that acted as intra-articular lubricants. Unfortunately, these methods were not as safe as they were claimed to be. They were linked to several potential side effects and the worst; they weren’t as effective as they were assumed to be.

In the year 1990’s scientists developed an interest of creating osteoarthritis drugs. Unfortunately, their efforts weren’t successful.

Stem cells for regrowing cartilage have become a center of interest. However, there are a few issues that need to be addressed. Many people still question which kind of stem cells are to be used and those that shouldn’t. There are also a few questions about how stem cells would work for regrowing cartilage, potential risks, how their productivity can be enhanced and more.


stem cells

Recently, there was a breakthrough in the area of human pluripotent stem cells. It was originally established in the year 2007 by Shinya Yamanaka; Yamanaka was able to obtain adult stem cells. He then reprogramed them to work as cord blood stem cells. The results were stem cells that could differentiate to form any cells in the human body. However, the procedure has been accompanied by several issues.

Currently, a scientist can obtain mesenchymal stem cells that are found in the bone marrow. These stem cells work just like any other stem cell if placed in a correct environment together with growth activators.

Mesenchymal stem cells can perform a variety of functions, but can be limited to several organs. The good news is, it works for cartilage. However, it isn’t easy judging whether the procedure is as effective as it is assumed simply because their findings aren’t clear. It has also been realized that using MSCs in areas that have no cartilage may result in some complications.

It is, however, evident that the effectiveness of this procedure is short term and safe considering several factors such as improvements of cartilage. There are also no reported risks of cancer which has been one of the issues revolving around the use of pluripotential stem cells.


Currently, we can say that MSCs is the best approach that is obtained from the bone marrow plus many growth factors derived from plasma that is rich in platelet. For a successful harvesting to take place, use of ultrasound guidance by a professional is highly advised.


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stem cells

Stem cells versus health industry

The many controversies revolving around stem cells has encouraged many people to focus on the potential drawbacks instead of the obvious benefits. Apparently, stem cells have proven to be quite beneficial in testing new drugs and curing serious illnesses. Some studies have proven that it can also cure several types of cancers.

Despite all this, its application has resulted in raging debates for some years. Initially, it was illegal and was only accepted by a few after a realization that it could be a solution to several complications including illnesses that had no cure. One question is, where do all these controversies come from? Are there other possible stem cell research application in future?

You may wonder why some people are against a medication that has proven to be a cure for several illnesses that were assumed to be untreatable before.

The main issue here is abortion. According to those who are opposing stem cell research, obtaining stem cells from a living embryo is indifferent to abortion simply because the embryo will be useless after testing. On the other hand, the proposers claim that incorporating stem cell therapy in the medical industry is promising to both the patients as well as families around the globe. This is because of stem cell therapy, unlike other previous ineffective treatments, has proven to work for several incurable illnesses such as Parkinson’s, Alzheimer’s as well as other cancer types.

What are stem cells and how do they help cure diseases?

Stem cells exist in human bodies. Their role is to maintain as well as repair the cells of the tissues. To do this, they only divide and repair when they are required to, for example when there is an injury to the tissues. They can also be found in other sources such as skeletal cells, bone marrow, blood vessels, teeth and bone marrow.


stem cells

It was not until recently when the scientists figured out a way to reprogram stem cells that can treat several complications and diseases. This has made it possible to use the stem cells to cure several illnesses that include cancer, blindness, and many others. Realization of this has encouraged even the pharmaceutical firms and consultancy to agree with the claims made by the scientists behind it.

Despite this, there are still some steps needed to improve the usefulness of the research. Stem cells can also be extracted from the organs, or the living blood of adults eliminating the issue of abortion hence encourage the research to continue. The drawback in using this method is that scientists claim that they are not as useful as the living embryos.

Even with the raging debates, it is clear that stem cell has revolutionized medicine. They have been used in testing new drugs that include tumor drugs; they also work best in regenerating damaged cells of the tissue and the best part, they can completely restore damaged tissue. The point is, stem cell research is promising to health sectors, but until it is fully accepted, there is a lot to be discovered.


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autologous stem cell

Risks of Autologous Stem Cell Procedure

Before you make a decision to go through autologous stem cell procedure, it is advisable to understand the risk behind it. Recent studies have shown that a child who has a family history related to inherited leukemia, sickle cell disease or black diamond fan is in danger of having a complication that might require a stem cell transplant. However, the probability might be low or high depending on several factors.

For example, there is a low chance of one in 20, 000 for families who don’t have any history related to any of the inherited complications. This can be evident in the finding that the autologous cord blood stem cell’s documented cases to date are only five.

There has been a lot of debates revolving around the use of autologous stem cells despite its proven benefits. The transplantation of autologous stem cell has been known to work well for several types of solid as well as hematological tumors.


autologous stem cell

According to an overview by Gradwohl et al., 2001, in the year 1999, 69% 18, 720 initial transplants were autologous. The 69% included up to 6,289 leukemia transplants, 8,219 lymphoma transplants, and 3,302 solid tumor transplants.

According to recent findings, these figures have increased significantly in the previous years. The main concern is not based on whether the transplantation of autologous progenitor cell has a purpose, but whether the cord blood will produce enough autologous cells in the coming years.

Among the controversies is an issue that questions several blood complications where the defect is related to genes and that can prevent the performance of autologous stem cells in therapy. According to a review by, Greaves, 2002, 1% of up to 600 samples of blood showed the existence of TEL-AML1 fusion gene that is known to be related to leukemia. It is apparent that up to 100% of those with this type of genes are at great risk. It is also apparent that these pre-leukaemia mimickers can’t be converted for a benefit.

The controversies behind the use of autologous cord blood are known to be influenced by the fact that most families prefer storing the cord blood after birth with an intention of using it to help the child’s sibling in future.

Among the victims are the siblings that are supposed to go through cardiac transplantation where the cellular cardiomyoplasty may be a requirement in the coming years. Another good example is a family with diabetic history who decided to keep the cord blood of their child for security following the research findings that the stem cell that is based on gene therapy may be cure diabetes.


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