Tag Archives: Hypogonadism

Inflammatory Neurodegenerative Disorders

Adipose Derived Stem Cells to Treat Inflammatory Neurodegenerative Disorders

There are very many neurodegenerative disorders that we humans have to battle with. Some of these neurodegenerative disorders are inflammatory. Inflammation is a common feature in some neurodegenerative diseases such Alzheimer’s disease (AD) and multiple sclerosis. Microglial cells, the resident macrophages of the central nervous system, become chronically activated and mediate pathology inducing inflammatory responses. This inflammation may be initiated as an immune response and while it does not cause the disease, it has been shown to aggravate the progression of the inflammatory neurodegenerative diseases. Contrary to what many people think, inflammation does not initiate neurodegenerative disease but there is evidence that chronic inflammation involving microglia and astrocytes contribute to disease progression. The inflammatory response has been implicated in Alzheimer’s disease, Parkinson’s disease and MS. Currently, a major question is whether inhibition of the inflammatory response has the ability to reverse or slow the symptoms of disease.

Typically, inflammation is a defense mechanism against diverse insults, designed to remove noxious agents and to inhibit their detrimental effects. It consists of an astounding range of molecular and cellular mechanisms and an intricate network of controls to keep them in check. In neurodegenerative diseases, inflammation may be triggered by the accumulation of proteins with abnormal conformations or by signals emanating from injured neurons. Given the multiple functions of many inflammatory factors, it has been difficult to pinpoint their roles in specific pathological situations. Studies of genetically modified mice and of molecular pathways in activated glia are beginning to shed light on this issue. Through different studies it has been found that altered expression of different inflammatory factors can either aggravate or counteract neurodegenerative processes. Normally, inflammation should be beneficial but for some reasons inflammation in neurodegenerative disorders can form grounds for aggravation of these neurodegenerative disorders and so a viable means of treatment that should suppress inflammation and inhibit progression of these disorders should be utilized to help in treatment of these inflammatory neurodegenerative disorders.

Adipose Derived Stem Cells

Inflammation and Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disease that is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. According to a new study, there are markers of inflammation in the cerebrospinal fluid that protects the brain and spine from injury. This study linked these markers to symptoms like fatigue, depression and anxiety in patients with Parkinson’s disease and it is hoped that this discovery may make the treatment of this disease much easier.

This study was led by Lena Brundin who is an associate professor at the College of Human Medicine at Michigan State University. This research was carried out as part of a team from Lund University in Sweden, Skåne University Hospital in Sweden and the Mayo Clinic College of Medicine in Jacksonville, Florida. The team measured a number of inflammatory markers in fluid samples of patients with Parkinson’s and in a control group without the disease.

“The degree of neuroinflammation was significantly associated with more severe depression, fatigue, and cognitive impairment even after controlling for factors such as age, gender and disease duration.” Prof. Brundin told the press.

However this is not the first study to link brain inflammation to Parkinson’s disease, there are previous studies that have linked it to non-motor symptoms like depression, fatigue and cognitive impairment. These past studies have indicated that inflammation in the brain could drive cell death, and drugs that target this process could offer new treatments to slow progression of the disease. For instance, a study published as far back as 2007 suggested that brain cell death in Parkinson’s may be reduced by blocking enzyme activity.

According to Prof. Brundin most of these previous studies looking at inflammatory markers in the cerebrospinal fluid of Parkinson’s patients have involved only small numbers of patients, often without comparing them to healthy controls. Despite this view, it is still evident that brain inflammation still has a role to play in aggravating neurodegenerative disorders.

Inflammation and Multiple Sclerosis

Multiple sclerosis is a disease of the Central Nervous System that is characterized by demyelination and inflammation. In a nutshell, MS is often described as an inflammatory demyelinating condition. Myelin is a layer of fatty that covers the nerves maintaining their health and flexibility. It is demyelination that causes spasms that are common with MS patients.

Adipose Derived Stem Cells

Adipose derived stem cell therapy for these inflammatory neurodegenerative disorders

Owing to the ability of the stem cells to differentiate many times and form different body cells, they have been used in the past to regenerate or better yet to replace damaged cells in the body and this has made them a target for treatment of vey many conditions, including neurodegenerative disorders.

The stem cell therapy is now being used to grow dopamine producing nerve cells in laboratories to aid the treatment of this disease. The stem cells are majorly used in the labs when the genetic cause of the disease is known. The disease destroys cells but through stem cells therapy, the damaged cells can be replaced by healthy new cells of the same type. There are also researchers who have since done extensive work in applicability of stem cell therapy in treating PD. through research it has been shown that by releasing various kinds of noxious factors such as cytokines or proinflammatory molecules microglia may damage CNS cells. The stem cell therapy can be used to restore the parts of the nervous system that are destroyed as a result of release of cytokines in inflammatory neurodegenerative disorders.

Finally, Neurodegenerative disorders have debilitating effects on patients and should be fought by all means. This is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to patients by availing integrative and safe treatment options to all our patients. In case you are troubled by any of these disorders, just call on Dr. Dalal Akoury (MD) today and begin your journey to victory against neurodegenerative disorders

Adipose Derived Stem Cells to Treat In Inflammatory Neurodegenerative Disorders

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Could you be at risk for Prostate Cancer?

The Effect of Testosterone Level On Risk Of Prostate Cancer

Introduction

In this article, we shall examine the effect of testosterone level on the risk of prostate cancer. This has remained a subject of great controversy because of the divergent views that have been fronted. Basically the argument has been that using testosterone therapy on men who have been treated of prostate cancer in the past exposes them to the risk of developing the cancer afresh. The reason given for this has been that the therapy could reawaken sleeping cancer cells in the body of the patient, thus triggering a new and aggressive attack.

On the other end of the spectrum has been the argument that testosterone therapy is not necessarily associated with cancer recurrence. And there have been studies to support this. We shall look at both sets of arguments in detail.

Testosterone Therapy

This is a common form of therapy that is widely used to treat a number of complications in aging men. With the process of aging comes a sustained decline in the amount of testosterone in the body of men. A decline in the amount of testosterone in the body is associated with a number of problems. For instance, men at advanced ages usually experience decreased libido. This effect can be attributed to a complex interplay of hormones within the body which is triggered by a reduction in the amount of testosterone. In the same manner, symptoms such as general fatigue and even other forms of sexual dysfunction (apart from the low libido mentioned) have been treated by use of testosterone therapy.

Prostate Cancer

Prostate cancer is a common form of disease in men of advanced age. Although studies have indicated that the disease is able to affect men of even lower ages, it has been common for the disease to be associated with advanced age. The complex interaction between different factors in the body of men at advanced ages has been studies and the results have indicated that the risk of development of prostate cancer in men increases rapidly as they advance in age. So, with a decrease in the amount of testosterone, which automatically occurs with an increase in age, comes a rise in the risk for developing prostate cancer. Although this is true, it is worthwhile to mention that currently, studies are being conducted to determine whether the relationship is as a result of decline in testosterone levels in the prostate alone or the body as a whole.

Testosterone and Treatment of Prostate Cancer

For men who develop prostate cancer, the standard treatment procedure has been a radical reduction of the hormones in the body. This procedure has been used in many cases in which prostate cancer has developed and metastasized fully. However, studies have indicated that in some cases, prostate cancer is able to withstand such a treatment and recur in the future, if triggered by existence of the right conditions. The manner in which this occurs has been attributed to the ability of prostate cells to produce testosterone at a much higher level than before the hormone-reducing therapy was administered. What this means is that even if the amount of testosterone in the body of a patient is dramatically reduced by the procedure, the amount in the prostate remains the same, thus compensating for the loss. Therefore, when the right conditions are created, the cells that produce excess testosterone may develop into cancer cells.

Testosterone Therapy & Prostate Cancer

Standard procedure for tackling prostate cancer in men has been through surgery, chemotherapy and even immunotherapy. However, history and studies have indicated that when men who have been successfully treated of prostate cancer are exposed to testosterone therapy later in their lives, the possibility of the prostate cancer reoccurring is highly increased. If this is so, then testosterone therapy becomes dangerous for men who have been successfully treated of prostate cancer before.

However, there have been arguments to the contrary. Since a lot of studies have been conducted on this matter, we summarize the most important points here as follows.

First, although some studies have indicated that giving the therapy to men who have been successfully treated of prostate cancer exposes them to the risk of developing the disease afresh, the degree of risk remains minimal, at the best. Since the association has not been firmly established, the balance of probability has been that whether or not to administer the treatment to such patients depends on the judgment of the specialist. It is safe to say that the outcome of using testosterone therapy in men who have undergone successful treatment of prostate cancer cannot be predicted with certainty.

Second, there has been evidence to suggest that men with low levels of testosterone are at a higher risk of developing prostate cancer compared to those having normal testosterone levels. Therefore, if such men seek testosterone therapy in the future the risk of developing the cancer remains. This is so because testosterone therapy is not used as a prostate cancer treatment method.

Concluding remarks

AWAREmed Health and Wellness Resource Center has been established as a leading center for cancer treatment. We offer our clients a wide range of services in relation to cancer diagnosis, treatment and general management. Feel free to contact Dr. Dalal Akoury, a leading specialist in alternative and complementary treatment of cancer, for an appointment.

The Effect of Testosterone Level on Risk Of Prostate Cancer

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The Effect of Testosterone Level On Risk Of Prostate Cancer


TestosteroneIntroduction
In this article, we shall examine the effect of testosterone level on the risk of prostate cancer. This has remained a subject of great controversy because of the divergent views that have been fronted. Basically the argument has been that using testosterone therapy on men who have been treated of prostate cancer in the past exposes them to the risk of developing the cancer afresh. The reason given for this has been that the therapy could reawaken sleeping cancer cells in the body of the patient, thus triggering a new and aggressive attack. On the other end of the spectrum has been the argument that testosterone therapy is not necessarily associated with cancer recurrence. And there have been studies to support this. We shall look at both sets of arguments in detail.

Testosterone therapy

This is a common form of therapy that is widely used to treat a number of complications in aging men. With the process of aging comes a sustained decline in the amount of testosterone in the body of men. A decline in the amount of testosterone in the body is associated with a number of problems. For instance, men at advanced ages usually experience decreased libido. This effect can be attributed to a complex interplay of hormones within the body which is triggered by a reduction in the amount of testosterone. In the same manner, symptoms such as general fatigue and even other forms of sexual dysfunction (apart from the low libido mentioned) have been treated by use of testosterone therapy. Prostate cancer Prostate cancer is a common form of disease in men of advanced age. Although studies have indicated that the disease is able to affect men of even lower ages, it has been common for the disease to be associated with advanced age. The complex interaction between different factors in the body of men at advanced ages has been studies and the results have indicated that the risk of development of prostate cancer in men increases rapidly as they advance in age. So, with a decrease in the amount of testosterone, which automatically occurs with an increase in age, comes a rise in the risk for developing prostate cancer. Although this is true, it is worthwhile to mention that currently, studies are being conducted to determine whether the relationship is as a result of decline in testosterone levels in the prostate alone or the body as a whole.

Testosterone and treatment of prostate cancer

For men who develop prostate cancer, the standard treatment procedure has been a radical reduction of the hormones in the body. This procedure has been used in many cases in which prostate cancer has developed and metastasized fully. However, studies have indicated that in some cases, prostate cancer is able to withstand such a treatment and recur in the future, if triggered by existence of the right conditions. The manner in which this occurs has been attributed to the ability of prostate cells to produce testosterone at a much higher level than before the hormone-reducing therapy was administered. What this means is that even if the amount of testosterone in the body of a patient is dramatically reduced by the procedure, the amount in the prostate remains the same, thus compensating for the loss. Therefore, when the right conditions are created, the cells that produce excess testosterone may develop into cancer cells.

Testosterone therapy and prostate cancer

Standard procedure for tackling prostate cancer in men has been through surgery, chemotherapy and even immunotherapy. However, history and studies have indicated that when men who have been successfully treated of prostate cancer are exposed to testosterone therapy later in their lives, the possibility of the prostate cancer reoccurring is highly increased. If this is so, then testosterone therapy becomes dangerous for men who have been successfully treated of prostate cancer before. However, there have been arguments to the contrary. Since a lot of studies have been conducted on this matter, we summarize the most important points here as follows. First, although some studies have indicated that giving the therapy to men who have been successfully treated of prostate cancer exposes them to the risk of developing the disease afresh, the degree of risk remains minimal, at the best. Since the association has not been firmly established, the balance of probability has been that whether or not to administer the treatment to such patients depends on the judgment of the specialist. It is safe to say that the outcome of using testosterone therapy in men who have undergone successful treatment of prostate cancer cannot be predicted with certainty. Second, there has been evidence to suggest that men with low levels of testosterone are at a higher risk of developing prostate cancer compared to those having normal testosterone levels. Therefore, if such men seek testosterone therapy in the future the risk of developing the cancer remains. This is so because testosterone therapy is not used as a prostate cancer treatment method.

TestosteroneConcluding remarks

AWAREmed Health and Wellness Resource Center has been established as a leading center for cancer treatment. We offer our clients a wide range of services in relation to cancer diagnosis, treatment and general management. Feel free to contact Dr. Dalal Akoury, a leading specialist in alternative and complementary treatment of cancer, for an appointment.

 

 

The Effect of Testosterone Level on Risk Of Prostate Cancer

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What Does Androgens Play in Men?

Role of Androgen in Men

androgens in menFor a man to be sexually activity and be able to perform well during sexual intercourse there must be the actions of some hormones. These hormones do a lot in enabling a man to perform better during sexual intercourse. Without these hormones it becomes hard for sex to be enjoyable. In some cases absence of these hormones can lead to erectile dysfunction. Erectile dysfunction has continued to be a worry in the lives of many men and just enough cases has been attributed to deficiency of the androgen in men.

Androgens are a group of sex hormones that are responsible for giving men their male characteristics. And hormones are chemical messengers. They communicate with tissues in the body to bring about many different changes.  They are very crucial for male sexual and reproductive function. They are also responsible for the development of secondary sexual characteristics in men, including facial and body hair growth, and bone and muscle development. Without sufficient androgens in the body of a man his may fail to achieve some of the masculine characteristics such as deep voice, broad chest and even the masculine physique. This therefore shows that that these hormones play a big role even in shaping the outward appearance of a man. There are hormones that are responsible for sexual functions in men but the major sex hormone in men is the testosterone hormone. This hormone is produced in the testes. The production of this hormone in the testes is controlled by the pituitary gland that is located in the brain. At times there might be a deficit of the male sex hormones in the body. This is referred to as Androgen deficiency. androgen deficiency is characterized by low levels of sex hormones especially the major sex hormone in a man’s body, the testosterone which is very essential for sexual health. There are very many causes of androgen deficiency. some may be as a result of a personal indulging in behaviors that are counterproductive to general body health or as a result of problems in the pituitary glands that controls the functions of the testes or when the testes has a problem that may maim their functions hence affecting the production of testosterone hormone.

Male climacteric

To begin with it is a known fact that women go through menopause and that is a period that productions of some crucial hormones in their bodies stops and this makes them unable to enjoy sex or other be actively in involved in sex as they were before reaching menopause. Men also go through this stage although hormonal fluctuations are not as abrupt as in women. They go through a gradual decrease in sex hormone levels from a longer time. This gradual decrease in sex hormones may begin at the age of thirty and continues gradually as they age.
Male climacteric is real and it happens in such a gradual process that may not be easily noticeable unlike in women where the drop in sex hormones is very abrupt. In men it takes time.

androgens in menFor this reasons old men who have reached 60 years of age are not as sexually active as a man in his early twenties. The hormone secretion is still not reduced at 20 and so men in this age tend to be very sexually active. The moment the testosterone levels drops due to age or due to sickness the sex drive of a man will tend to go low even his appetite for sex and the overall performance during sexual intercourse also becomes reduced.

Married men who have reached male climacteric ages but still needs to be sexually active often seeks the aid of other therapies like the testosterone replacement therapy to increase their testosterone levels in the body so that they can be able to regain their sex drive and be able to perform satisfactory sex to their women.

Male climacteric is a natural condition and should not be confused with erectile dysfunction. Whereas erectile dysfunction needs medical attention, male climacteric is a stage just like puberty that does not need to be treated. However as a man sexual needs may command him he may seek various interventions to increase his performance in bed like the use of sex pills.

There are other functions of the androgens except from the sexual functions. The androgens are also responsible for the strength of bones and muscles. This explains why old men will need the support of a walking stick to maintain their stability as the bones are not strong due to the lower levels of androgen in the body. In case of deficiency in androgens before the right age it is advisable to seek medical help as that is not a natural process. There should be optimum levels of the androgens in your body during your youth in absence of which there must be underlying serious disease that must be treated. However it is better to know your sexual health status, if you are experiencing symptoms of low androgen levels such as low sex drive, lethargy or low sperm production you should seek help to make your sex life more fun and enjoyable.

Dr. Dalal Akoury (MD) is an experienced doctor that has helped many cancer patients in their fight against the disease. She has also helped many people regain their sex appetite and add more fun into their sex life. She founded AWAREmed Health and Wellness Resource Center which is home to many people seeking health breakthrough. Call on her now and learn more on how to enhance your sexual health.

Role Of Androgen In Men

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Understanding Testosterone Replacement Therapy

Testosterone Replacement Therapy

Testosterone Replacement TherapyErectile dysfunction is a disease that must be fought at all angles. The body is aided by several hormones to work favorable. There are very many hormones in the body that perform different functions. Without these hormones the body may fail to perform effectively some of its processes. Sex is a process not an event. I think we need to appreciate this fact early enough lest you will not be doing anything meaningful reading this article. The process of sex involves very many things and one of the most needed paraphernalia for this process to be effective is the hormones. Hormones particularly the testosterone hormone plays a great role in sex performance. This is the hormone that make the man able to sexually satisfy a woman without this hormone even the urge to have sex is lost in a man. This therefore means that when this hormone is inadequate in levels then a man cannot achieve a lasting erection long enough to satisfy a woman. However the production of this hormone may fluctuate due to health issues or even as a result of age. As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. This therefore means that for a man to be active in sex, he should find a way to supplement testosterone as what the body now produces is not enough to keep the fire burning. One of the ways of supplementing the testosterone in the body is through Testosterone replacement therapy. However not all cases of erectile dysfunction are caused by inadequate production of hormone testosterone. There are other causes of erectile dysfunction but in cases where low testosterone levels is the cause then it can be cured by Testosterone replacement therapy. As all of you may know now testosterone is a crucial hormone in a man’s life as it is responsible for the proper development of male sexual characteristics. It is also important for maintaining muscle bulk in men, adequate levels of red blood cells, bone growth, a sense of well-being, and sexual function. Testosterone hormone is produced in the testicles.

A condition in which the body is not able to produce enough amounts of testosterone due to problems with the testicles or the pituitary glands that control the functions of the testicles is referred to as Hypogonadism. To restore the normal levels of testosterone in the body, testosterone replacement therapy can be done.

Testosterone replacement therapy

Testosterone replacement therapy involves supplementation of testosterone inform of injections, pellets, patches or gel in order to treat conditions in which the testes do not produce enough testosterone. It is also available in IV forms. Just like the estrogen replacement therapy in women, this ought to be done by an expert as the dosage is important for better results and to mitigate on the side effects. This therefore cannot be done without the help of an expert. This therapy has been found to be effective in fighting hypogonadism. It is also good in improves energy levels, perfect body mass, sex functions and muscle strength among other benefits.

The benefits of testosterone replacement therapy

Every person needs a sound sex life and if you are a victim of erectile dysfunction you may want to use the testosterone replacement therapy. If your case is as a result of hypogonadism, you benefit from the testosterone replacement therapy as it increases the levels of testosterone hormone in the body and hence it may reverse the effects of hypogonadism and restore your vibrant sex life. Other benefits of testosterone replacement therapy include;

  • Improves masculinity

One of the functions of the testosterone hormone is to emphasize the expression of men features. The testosterone replacement therapy ensures a lean body mass and helps in controlling weight while increasing energy at the same time. Testosterone has been found to have a good effect in decreasing the body fats while increasing muscle size and strength.

  • Gives strength to bones

Testosterone Replacement TherapyA study finding that was published in the Journal of Clinical Endocrinology & Metabolism showed that aged men can increase their bone density with testosterone replacement therapy. Testosterone hormone helps in strengthening bones hence giving support to muscles and other internal organs. However as a man grows old the levels of this crucial hormone drops in the body to weaker bones. It is therefore necessary for testosterone therapy to restore the bone strength and reduce their risk to osteoporosis.

  • Increases libido

Testosterone plays a major role in sexual activity. During sexual arousal the levels of testosterone heightens but it decreases in seasons of abstinence. Without this hormone libido becomes low and sexual activity is inhibited. Through testosterone replacement therapy libido is increased. It boosts sexual desire in men and even performance.

Disadvantages of testosterone replacement therapy

There are risks that have been associated with testosterone replacement therapy. Some of these risks include;

  • increases the risk of heart attack
  • Causes a sleeping disorder known as apnea which is characterized by stops and starts in breathing.
  • It also cause acne among other skin reactions
  • It may reduce sperm count and cause testicles to shrink
  • It may cause breast enlargement in men
  • Increases the risk of deep vein thrombosis which involves a blood clot forming in the veins. This clot may get logged in the lungs causing pulmonary embolism.

Dr. Dalal Akoury (MD) is an experienced doctor that has helped many cancer patients in their fight against the disease. She has also helped many people regain their sex appetite and add more fun their sexual life. She founded AWAREmed Health and Wellness Resource Center which is home to many people seeking health breakthrough. Call on her now and learn more on how to enhance your sexual health.

Testosterone Replacement Therapy

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