Tag Archives: Metastasis

Angiogenesis Inhibitors and Cancer

Angiogenesis Inhibitors Play A Great Role In Cancer Treatment

AngiogenesisMetastatic static cancer is a fear of every cancer patient. Metastasis makes it hard for cancer to be treated. However cancer cannot metastasize without angiogenesis which is the sprouting of new blood vessels. The oncologists can best avoid metastasis by avoiding angiogenesis which is only achieved by use of angiogenesis inhibitors.

Angiogenesis defined

Angiogenesis is a process through which blood vessels are formed. Angiogenesis occurs naturally during the growth and development of children. The mother’s womb has to form new blood vessels that are important in the development of the infant. This is a crucial process in the foetus. However in adults this process happens less often and may happen during wound healing. In women it happens during the menstruation cycle. When this formation of new blood vessels is induced by tumor, it is referred to as tumor angiogenesis. This happens when the tumors release molecules that signal the surrounding tissues. It is this signaling that activates genes that make proteins to initiate growth of new blood vessels. These new blood vessels penetrate into the cancerous cells and help them grow by supplying them with the needed nutrients and removing wastes out of them hence creating an environment that favors their growth and metastasis.

Without angiogenesis tumors cannot grow and metastasize, it is therefore a necessity without which the cancerous cells will become inactive and will even die. When the new blood vessels have been formed it become hard for the cancer to be treated. The cancer patient will have to endure pain as the tumors will be growing at a faster rate since they have adequate nutrient supplies which they receive though these newly formed blood vessels therefore they can be controlled when these nutrient supplies are cut and that is what angiogenesis inhibitors does.

This discovery that cancer cells depend on angiogenesis to grow and metastasize has led to development of many cancer treatments that target angiogenesis. These therapies can be very effective in fighting this disease since it doesn’t affect the healthy body cells. Moreover if angiogenesis can be inhibited then all cancers can be controlled since it is a necessity for growth of tumors in all cancers. When angiogenesis is inhibited the cancer cells are denied of their supplies and they will automatically die of starvation.

Copper is a necessity for Angiogenesis

Copper is a trace element the needs to highly regulated as any slight homeostatic copper disruptions may result in serious health complications such as the Wilson’s disease. Copper is necessity for angiogenesis. Without copper angiogenesis cannot take place. It is therefore evident that Copper fuels cancer tumor growth and metastasis. Angiogenetic inhibitors can be used to curb this situation. Tetrathiomolybdate (TM) is effective in copper chelation.  Researchers have proved that TM forms a stable tripartite complex with copper and protein. When given with food, it chelates food copper with food protein and inhibits absorption of copper in the bloodstream. There is endogenous secretion of copper in saliva and gastric secretions associated with food intake, and this copper is also chelated by TM when it is taken with meals, thereby preventing copper re-absorption.

Medical researchers have done test on the effectiveness of the tetrathiomolybdate (TM) on mice that were injected with cancer cells and left for a week for angiogenesis to begin. After the new blood vessels had been formed the mice was injected tetrathiomolybdate (TM). The angiogenesis stopped and the tumor growth stopped. However from researches that had been done in the past it was concluded that tetrathiomolybdate (TM) has a unique action on the copper that fuels angiogenesis and retarded tumor growth with minimal side effects. When cancer patients are given TM with food they get a negative copper balance which is not good angiogenesis. The copper that is bound by TM cannot do any meaningful biological activity as it cannot be absorbed by cells and is excreted in the urine having been cleared by bile hence tamed.

Normally, the level of copper that is needed for angiogenesis is much higher as compared to the amount of copper that is needed for cellular activities that are dependent on cancer like cytochrome function and heme synthesis. Cancer therapy that are based on anti-copper may work well as the copper needed for cellular activities will be retained even when TM is used to as an anti-copper angiogenic agent.

Low molecular weight heparins inhibits metastasis

AngiogenesisIt has also been found out that Low molecular weight heparins helps in improving the cancer patient’s chances of survival as it inhibits metastasis. The low molecular weight heparins are able to inhibit metastasis by preventing cancer cell triggered destruction of the endothelial glycocalyx. In experimental animal models and clinical tests; it was found that the low molecular weight heparins protects against cancer progression and metastasis. The scientists say this is possible as the low molecular weight inhibits metastasis interfering with the cancer cell binding on the platelets. Cancer cell needs to attach themselves to the platelets to move to other parts of the body. Low molecular weight heparins also inhibit metastasis through binding of heparanase or hyaluronidase thereby protecting the vascular endothelium from invasion by the cancer cells.
Dr. Dalal Akoury (MD) is an experienced integrative cancer doctor that has helped many cancer patients in their fight against the disease. She has worked hard not only in treating the disease but also in availing informational support to cancer patients at Awaremed which has become a place called home for many cancer patients. Call on her now and get help on cancer.

Angiogenesis Inhibitors Play A Great Role In Cancer Treatment

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Phytomedicine In Cancer Treatment

Phytomedicine and DIM Can Effectively Be Used In Triple Negative Breast Cancer Treatment

phytomedicinePhytomedicine refers to the application of scientific research and the highest standards of professionalism to the herbal medicine practice. The use of phytomedicine is not new though. It has been in practice for quite a long time in fact  the name phytomedicine is derived from the word used in other parts of Europe, where plant based medicines are provided by doctors and pharmacists as ‘phytomedicine’ to their patients. Phytomedicine is more advanced in herbal medicine as it involves scientific research to ascertain the potency of the natures given herbals before they are prescribed to be used by any patient. The doctors who use phytomedicine are called phytotherapists and they treat their patients with the best herbs that fit their king of diseases. Phytotherapists choose the best herbs from the most effective herbs ensuring that very patient get the best combination of the phytomedicine.

Phytomedicine is practiced in clinical treatment of diseases in most parts of the world and is a growing field as it involves scientific research and information on the use of plant medicinal components and their safety in use. There are methods that are used to evaluate the effectiveness of plant medicines which are similar to the evaluation of orthodox medicine. Herbs unlike the orthodox medicine that focus on given chemicals contain very many bioactive components. The phytomedicine may involve use of a combination of herbs to come up with a therapy that will heal the body and strengthen its immune system to fight diseases better.

Phytomedicine are safe for use for many diseases and cancer is no exception. After very many clinical trials of phytomedicine the use of phytomedicine in treatment of various conditions have been recognized in most countries through the world. Section 12 (1) of the 1968 Medicines Act permits Phytotherapists to make and dispense herbal remedies to individual patients following a consultation.

As used in cancer treatment, Phytomedicine involves selection of plant medicines to stimulate or strengthen the body’s own functions and immune system, hence support the body to heal itself. The phytotherapist knows that each cancer patient is a unique individual and hence diagnoses and assesses the needs of the cancer patient uniquely. The patient will thereafter be given a prescription of combined plant products that work best in healing them.

Some of the natural plants components that have been used in phytomedicine to treat cancer include; resveratrol, saponins, silymarin, curcumin, peach compounds, green tea extracts, coffee enemas and grape seed extracts. These phytomedicine are rich in anticancer properties and are even safer for use in cancer treatment. The use of chemotherapy in cancer treatment may fail to work and if chemotherapy is done repeatedly the tumors only become more resistant to the drugs that are supposed to be killing them. The scientists have found out that the use of natural products work better in cancer treatments as they target multiple pathways thereby inhibiting growth and spread of the cancer cells in the body. Some of this phytomedicine help in killing cancer cell by inducing apoptosis in tumors.

EGCG and GSE are two popular plant extracts that have attracted much attention in recent years due to their antioxidant, antimicrobial, anticarcinogenic, and anti-inflammatory properties.

Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is the most difficult cancer to treat as these cancer cells are very resistant to drugs. These cancer cells do not have the characteristic receptors for estrogen, progesterone and Her2/neu. This makes it very hard to treat a patient with Triple negative breast cancer (TNBC) as most treatments especially the conventional cancer treatments target these receptors that are missing in the cells. Without these receptors such treatments do not work. For instance, Tamoxifen targets estrogen receptors, in absence of estrogen receptors Tamoxifen cannot work in cancer treatment. For this reason, TNBC is considered the most aggressive, the most likely to be treated with less-targeted (and therefore more toxic) forms of chemotherapy, and the soonest to return when treatment fails. For Triple negative breast cancer (TNBC) target therapies are not the best options for treatment.

Today it is approximated that between 15-25% of all breast cancer cases are triple negative. Being that the conventional cancer treatments cannot be used in treatment of Triple negative breast cancer it is important to seek effective treatment through other means. Phytomedicine can effectively be used in treatment of Triple negative breast cancer (TNBC) as it works better here than any other target therapies.

DIM

Recent research has shown that diindolylmethane (DIM) promotes production of beneficial interferon gamma by breast cancer cells. With reference to scientists at the University of California, Berkeley, the anticancer effect of DIM is evident as the interferon gamma is known to play an important role in inhibiting the development of primary tumors. It has also been proven that DIM increases cellular stress response pathways in breast, prostate and cervical cancer cells. The increase of cellular stress increases the vulnerability of cancer cells to destruction. Studies have shown that DIM induces apoptosis in both breast and prostate cancer cells.

PhytomedicineAccording to a study done by Scientists at Wayne State University School of Medicine, DIM affects the functions of genes that control carcinogenesis, cell survival, and physiologic behaviors. It also inhibits the growth of new blood vessels that are necessary for spread and growth of tumors. In a the study that was conducted by University of California, Berkeley it was found that DIM inhibited angiogenesis on both cultures assays as well as animal models. It is therefore effective and can be used in treatment of Triple negative breast cancer (TNBC).

Dr. Dalal Akoury (MD) is an experienced integrative cancer doctor that has helped many cancer patients in their fight against the disease. She has worked hard not only in treating the disease but also in availing informational support to cancer patients at Awaremed which has become a place called home for many cancer patients. Call on her now and get help on cancer.

Phytomedicine and DIM Can Effectively Be Used In Triple Negative Breast Cancer Treatment

 

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Matrix Metalloproteinase Inhibitors

Matrix Metalloproteinase Inhibitors Are Gaining Popularity In Cancer Treatment

Cancer cells just like the healthy normal body cells have specific process that have to be accomplished in order for them to survive. Cancer doctors have known this for a long time and most of the alternative cancer treatments that we have today are best on the understanding of certain survival mechanisms. There are certain cancer treatment alternatives that are geared towards making them more vulnerable to chemotherapy drugs and are hence used alongside the chemotherapy as well as other conventional cancer treatment medications like radiation therapy. There are other more effective cancer treatment alternatives that aim at interfering with the cancer cell metabolism mechanisms hence starve them by denying them the ATP energy that they need to accomplish some of their cellular functions like growth and division to give rise to new cancer cell. The use of alternative cancer treatment are gaining popularity not because the conventional cancer treatment medications do not work but to find better ways of treating cancer patients by targeting the cancer cells while safeguarding the healthy body cells. This is a loophole that has to be filled. In conventional medicine the treatment targets killing of the cancer cell but the healthy body cells are also affected by the chemotherapy drugs and they die as well leaving the patient with lots of side effects that are very life threatening. The cancer doctors and researchers are trying to treat cancer strategically so that the patient is not put through the pain of going for repeated chemotherapy. Due to these different alternatives to cancer treatments that work effectively in different cases to combat cancer, the new breed of cancer doctors; the integrative doctors have become a favorite for cancer patients. This is because they are very knowledgeable in oncology and puts in use all the alternative cancer treatments (naturopathic) and the conventional cancer treatment in a bid to achieve a whole person healing of the cancer patient.

One of the best ways of treating cancer is to use inhibitors. These inhibitors affect the normal functioning of the cancer cells and hence a slow their growth and survival rates. Some of these inhibitors are also strong enough to induce apoptosis of the cancer cells. Matrix metalloproteinase inhibitors are some of the inhibitors that help in strategic fighting of cancer.

Matrix metalloproteinases, often known as MMPs are a group of enzymes that are involved in a number of normal cellular processes, such as regulation of endometrial growth and menstruation, and abnormal processes, such as tumor growth, invasion, angiogenesis, and metastasis. Matrix metalloproteinases play a major role in angiogenesis. This is because they degrade the basement membrane and stromal tissue which is an important process for migration of endothelial cells needed to form new blood vessels. They also play an important role in the entry and exit of tumor cells into the blood vessels hence foster metastasis. Due to their critical contributions in angiogenesis and metastasis they can be strategically targeted in cancer treatment by utilizing Matrix metalloproteinases inhibitors that will main all their activities.

Matrix metalloproteinases can be produced in two ways; either the tumor cells produce them themselves or they tissues surrounding the cancer cell produce them. Because of their role in cancer etiology they are highly regulated especially through gene expression. They are secreted in inactive forms and must be cleaved to be active. Moreover they activities are also controlled by the Matrix metalloproteinases inhibitors that surround the tumor cell.

Researchers have done lots of work in trying to investigate if the matrix metalloproteinase inhibitors can be used to maim the functions of the Matrix metalloproteinases and help in cancer treatment. Their research are based on the logic that Matrix metalloproteinases are crucial enzymes for tumor invasion and metastasis and is targeted the spread of cancer can be curbed. This treatment however does address the formation of primary tumors but again it can work in controlling the spread of tumor hence important.

Doxycycline as a Matrix metalloproteinases inhibitor

Doxycycline is a semisynthetic, chemically modified tetracycline compound that is rapidly absorbed and exerts biological effects courtesy of its antimicrobial activity. It has been used in the past in wound treatment and is also one of the most effective Matrix metalloproteinases inhibitor.

Clinical as well as lab tests have been one to show the effectiveness of Doxycycline in inhibiting Matrix metalloproteinases activities. As all these activities were done with a view of finding a possibility of using it in curbing metastasis. The study pointed out that an enzyme; MMP-2 is needed for the cancer cells to dig in or other to penetrate the normal tissues. Doxycycline has an inhibitory effect on the MMP-2 expression. This was verified by a lab test on smooth muscle cells and human aortic aneurysm tissue explants. The test revealed that Doxycycline inhibited the activities of MMP-2 on these tissues. However for effectiveness the concentration of the Doxycycline matters in its activity against the MMP-2. In the normal serum concentration just 5ml of Doxycycline affects the production of MMP-2 greatly.

By use of Matrix metalloproteinases inhibitors like Doxycycline, the cancer treatment becomes more effective and strategic as the cancer cells become targeted. With controlled metastasis and growth of cancer cells the patient can have a longer life and possibly the disease will be managed done with completely by an integrative cancer doctor who will combine other therapies to make the treatment more effective.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has seen very many cancer patients journey to victory in their fight against cancer. She is available for consultations. Just call her now and begin your journey to victory against cancer.

Matrix Metalloproteinase Inhibitors Are Gaining Popularity In Cancer Treatment

 

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Noscapine And Cancer

 

Research Shows That Noscapine Is Good In Fighting Cancer

noscapineCancer researchers have done lots of work in a bid to find how this dangerous disease can be tamed or better yet done away with completely. There are many discoveries that had been made in the past and each of these discoveries is based on given philosophies. These findings have seen us have many alternatives to cancer treatments. However cancer research is a very active field that is not about to go quiet any soon. Doctors and researchers are still in pursuit of a better way to treat cancer more effectively with fewer side effects. The conventional cancer treatment methods, the naturopathic cancer treatments as well as other available alternative cancer treatments have been used in the past either solely or integrative and the effects on cancer patients treatment analyzed. However as known types of cancer as well as personal bodily reactions make these treatments have unique outcome in particular patients. In some instances they have worked well but in some they have not and this is a reason enough to keep the cancer doctors working around the clock to come up with better treatment methods.

The spread of cancer is dependent on other processes in the body. Before these processes are accomplished then cancer cells can not spread to other body parts. Recently we learnt that metastatic cancer cannot take place without angiogenesis. So doctors can use that loophole to stop metastasis. If angiogenesis is stopped then the spread of cancer is curbed. Another research has also found out that mitosis plays a major role in cancer cell survival and spreading. It is therefore necessary that various ways of inhibiting mitosis be employed to help in cancer treatment.

Noscapine is a medicinal compound found in plants of the poppy family which unlike morphine is not a pain killer nor is it addictive. This compound has been used in the past as a cough suppressant in different over-the-counter medications. Recent research has however discovered that this compound is not only good for use as a cough suppressant but can also be used in cancer treatment

Noscapine inhibits mitosis

Mitosis is a process by which body cells duplicates themselves forming genetically identical cells from the parent cell. Mitosis in the case of cancer cells will lead to multiplication of cancer cells making it hard for the spread of the disease to be curbed. Mitosis occurs through spindle formation. During spindle formation, spindles pull chromosomes to the opposite sides of the cell in preparation for the cell division. Without spindle formation the survival of the daughter cells is not possible as they are separated without getting the appropriate genetic composition from the parent cell. Noscapine inhibits spindle formation therefore making it hard for the newly divided cancer cells to survive hence it affects mitosis which in turn helps in fighting cancer.

However this compound does not only help in cancer treatment by inhibiting spindle formation. Research has shown that this compound can work on varied ways to fight cancer. It has very powerful anticancer ability. This compound is said to contain strong cell killing properties that enables it to kill cancer cells before they duplicate and spread to other body parts.

Noscapine is also very effective as an anti-angiogenesis. Angiogenesis is the formation of new blood vessels. Cancer cannot spread without angiogenesis as it is through angiogenesis that that the tumors get fed. Supplies like nutrients pass through these new blood vessels to reach the tumors and so if angiogenesis cannot happen then the growth and spread of the tumors will be inhibited and the tumor cells will be starved. It does this by inhibiting HIF-1 alpha which supports the vascular endothelial growth factor (VEGF). Vascular endothelial is known to stimulate the growth of new blood vessels.

Noscapine is also beneficial as it inhibits another powerful cancer growth factor known as the bradikinin. Scientists have opined that any drug that can inhibit bradikinin can be very essential in cancer treatment just as chemotherapy. In fact majority of research findings point out those agents that inhibit bradikinin are better at reducing cancer cell growth than chemotherapy.

Because of its strong anticancer abilities, very many doctors have begun using Noscapine in cancer treatment. Especially in treating the following types of cancer; breast, prostate, lung, ovarian, brain, and lymphomas. Though it has been used as an effective cough suppressant, Noscapine can be a very powerful drug in fighting cancer if recent research findings are to be believed.

Another research done in 2010 Current Drug Targets showed that Noscapine was not only effective in inhibiting the growth of cancer cells but also made them more vulnerable to chemotherapy drugs. In fact that may benefit cancer patients on chemotherapy.

The above research is not the only one that endorsed the effectiveness of Noscapine in cancer treatment. Information that supports Noscapine as an effective anti-cancer agent was found in the medical research finding. The study said that Noscapine was the most effective anticancer after it was discovered that it causes cancer cell apoptosis. The experiment used Mg-63 tumor cells which are a common type of tumor of the bones.

nascopineDoctors are using Noscapine in cancer treatment and one of the doctors who have come out openly to be using the noscapine is from San Diego. He is known as Dr. Israel Barken. However he has been using it to treat his prostate cancer patients alone. He availed information on his website that proved that Noscapine reduced prostate cancer in mice greatly.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has made it her duty to help you stay cancer free by availing valuable information about cancer on this website. You can contact her for consultations.

Research shows that Noscapine is good in fighting cancer

 

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Angiogenesis and Metastasis

 The Role of Angiogenesis Inhibitors In Integrative Cancer Care
Cancer patients always have a fear that their cancer may become metastatic. If it becomes metastatic it becomes a problem to treat and may cause lots of damage to the healthy cells in the patient’s body. Metastastasis however cannot happen without angiogenesis. Therefore if the cancer doctors find a way of avoiding angiogenesis then it can be easier to avoid metastatic cancer. One of the known characteristics of cancerous cells is that they divide rapidly and their growth is uncontrolled, this is a major challenge as the danger increases with how well they are well spread in the body. The best way to control the spread of cancer is to control angiogenesis by the aid of angiogenesis inhibitors.

What is angiogenesis?

Angiogenesis is the formation of new blood vessels. This is a natural process that occurs majorly during growth and development of children. The mother’s womb has to form new blood vessels that are important in the development of the infant. This is a crucial process and is known as vascologeneis. However this process happens less often in adults and may happen during wound healing. In women it happens during the menstruation cycle. When this formation of new blood vessels is induced by tumor, it is referred to as tumor angiogenesis. This happens when the tumors release molecules that signal the surrounding tissues. It is this signaling that activates genes that make proteins to initiate growth of new blood vessels. These new blood vessels penetrate into the cancerous cells and help them grow by supplying them with the needed nutrients and removing wastes out of them hence creating an environment that favors their growth and metastasis.

For tumors to grow and metastasize, angiogenesis is a necessity without which the cancerous cells will become inactive and may even die. The network of newly formed blood vessels become very dangerous to the cancer patient as they enhance the growth of the cancerous cells, spreading to other parts of the body and inflicting pain. For this situation to be controlled there is need to cut the nutrient and oxygen supply to these cancerous cells.

Being that cancer cells depend on angiogenesis to grow and metastasize, cancer  therapies that target  angiogenesis can potentially help in treating cancer. Angiogenesis is necessary for growth and metastasis of all cancer cells irrespective of the type of cancer. Cancer treatments that target angiogenesis will definitely aid in treatment of all cancers. The basis of therapies that target angiogenesis is that if angiogenesis can be stopped then the cancerous cells will be killed as they will not access the necessary supplies hence will starve to death.

Copper and Angiogenesis

Copper is a trace element the needs to highly regulated as any slight homeostatic copper disruptions may result in serious health complications such as the Wilson’s disease. Copper is also known to be necessary for angiogenesis. Without copper angiogenesis cannot take place. Copper therefore fuels cancer tumor growth and metastasis. Anti-angiogenic therapies can be used to curb this situation. tetrathiomolybdate (TM) is effective in copper chelation.  Researchers have proved that TM forms a stable tripartite complex with copper and protein. If given with food, it chelates food copper with food protein and prevents absorption of copper in the bloodstream. There is endogenous secretion of copper in saliva and gastric secretions associated with food intake, and this copper is also chelated by TM when it is taken with meals, thereby preventing copper re-absorption.

Researchers have tested the effects of the tetrathiomolybdate (TM) on mice that were injected with cancer cells and left for a week for angiogenesis to begin. After the new blood vessels had been formed the mice was injected tetrathiomolybdate (TM). The angiogenesis stopped and the tumor growth stopped. Tetrathiomolybdate (TM) is targeted by many researchers who want to verify if it can be used as a cancer treatment. However from researches that had been done in the past it was concluded that tetrathiomolybdate (TM) has a unique action on the copper that fuels angiogenesis and retarded tumor growth with little side effects. If cancer patients are given TM with food their copper balance become negative which does not support angiogenesis. The copper that is bound by TM cannot do any meaningful biological activity as it cannot be absorbed by cells and is excreted in the urine having been cleared by bile.

Typically the level of cancer that is needed for angiogenesis is much higher as compared to the amount of copper that is needed for cellular activities that are dependent on cancer like cytochrome function and heme synthesis. Cancer therapy that are based on anti-copper may work well as the copper needed for cellular activities will be retained even when TM is used to as an anti-copper angiogenic agent.

Low molecular weight heparins

Researchers have also found out that Low molecular weight heparins helps in improving the cancer patient’s chances of survival as it inhibits metastasis. The low molecular weight heparins are said to curb metastasis by preventing cancer cell triggered destruction of the endothelial glycocalyx. In experimental animal models and clinical tests; it was found that the low molecular weight heparins protects against cancer progression and metastasis. This is said by the scientists is possible as the low molecular weight inhibits metastasis interfering with the cancer cell binding on the platelets. Cancer cell needs to attach themselves to the platelets to move to other parts of the body. Low molecular weight heparins also inhibit metastasis through binding of heparanase or hyaluronidase thereby protecting the vascular endothelium from invasion by the cancer cells.

Dr. Dalal Akoury (MD) is an expert in integrative cancer treatment and can avail you the best advice to help you cure or better yet prevent cancer. You can always call her for consultations.

 The Role of Angiogenesis Inhibitors In Integrative Cancer Care

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