Tag Archives: Nicotinamide adenine dinucleotide

Cocaine addiction

Rebuilding Neurotransmitter for addiction solution

Rebuilding Neurotransmitter

Rebuilding Neurotransmitter for addiction solution very essential in keeping immunity system free from drug abuse

Rebuilding Neurotransmitter for addiction solution: Recovery using Intravenous NAD & amino acids

Addiction is a disease and not a moral weakness as it was used to be seen in the past. Like any other disease, treatment is very essential and it should begin with the rebuilding neurotransmitters. This way, we will be addressing the core problem in all areas including body and mind. The successful therapy will depend on address both problems simultaneously because the health of both depends on the unity of both that facilitates the health and balance in the mind and body thereby providing highly effective therapy for addiction. Meaning that if you detoxify, or withdraw, from alcohol or a drug, without addressing the conditions in the body that create fatigue, depression, and anxiety, then relapse is more likely moments after the therapy has been incomplete. Similarly, if you withdraw from a substance and do not understand the psychological and spiritual issues that promoted the need for it, then relapse is likely and the hard lessons of disease (addiction) shall not have been learned says doctor Dalal Akoury MD, President and founder of AWAREmed health and wellness resource center.

Rebuilding Neurotransmitter for addiction solution: The body

Integrative, or, functional medicine provides the tools to assess and treat the conditions in the body that contribute to fatigue, depression, and anxiety, thereby increasing the likelihood of chemical dependency.  This include:

  • Nicotinamide adenine dinucleotide (NAD) deficiency
  • Neurotransmitter deficiency (serotonin, GABA, adrenaline, noradrenaline, dopamine, etc)
  • Metabolic cofactor deficiency
  • Pyroluria
  • Hypothyroidism
  • Adrenal fatigue
  • Intestinal yeast overgrowth
  • Delayed-onset food sensitivities
  • Gluten intolerance

These “terrain issues” in the body need to be properly treated in order to make detoxification easier and to prevent relapse.

Rebuilding Neurotransmitter for addiction solution: The mind and the spirit

Away from the body, addiction is also a disease in the mind. The fact that the mind rules the body is, in spite of its neglect by biology and medicine, the most fundamental fact which we know about the process of life. The origins of most physical disease are within consciousness. The body is the messenger of the conflicts, sustained fears, suppressed emotional traumas, disturbed patterns of thinking, and other imbalances that lie within the conscious and unconscious mind. Many people have painful childhood experiences, including patterns of neglect, smothering control, abandonment, and emotional, physical and sexual abuse.

Later on, there can be failed relationships, years of marital conflict, and the pain of loneliness. Many experience decades of unfulfilling employment, foiled personal creativity and the quiet desperation of a slowly dying spirit. These life experiences contribute to relentless anxiety, depression, denied emotions, destructive beliefs, hopelessness, helplessness, “giving up”, and an endless variety of recurrent stresses. And remember that the emergence of disease of any kind is the body’s way of getting your attention and inviting this self-exploration, thereby offering true healing which becomes possible by rebuilding neurotransmitters. Finally, having been with us all this time, we would not have done you any justice by leaving your concerns unaddressed, and for us to do that, you need to schedule an appointment with doctor Akoury today and all your concerns will be addressed professionally.

Rebuilding Neurotransmitter for addiction solution: Recovery using Intravenous NAD & amino acids


Drunk young man resting head on bar counter

Nicotinamide Adenine Dinucleotide (NAD)

Nicotinamide Adenine Dinucleotide

Nicotinamide Adenine Dinucleotide (NAD) and did you know that for every beverage alcohol you take about 2 to 8 percent is lost through urine, sweat, or the breath?

Nicotinamide Adenine Dinucleotide (NAD): Acetaldehyde and Alcoholism

Did you know that for every beverage alcohol you take about 2 to 8 percent is lost through urine, sweat, or the breath? This means that the other 92 to 98 percent is metabolized by your body. All ethyl alcohol which is broken down in the human body is first converted to acetaldehyde, and then this acetaldehyde is converted into acetic acid radicals also known as acetyl radicals. Acetaldehyde is a poison which is a close relative of formaldehyde. Acetic acid is the essential component of vinegar. The acetic acid radical is the combining form of acetic acid. This acetic acid radical combines with Coenzyme A to form acetyl-CoA. The acetyl-CoA then enters the Krebs cycle, which is the basic powerhouse of the human body. Inside the Krebs cycle, this acetyl radical is eventually broken down into carbon dioxide and water.

According to the experts from the AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD, there are three different enzymes the body uses to convert alcohol to acetaldehyde. The three enzymes work by stripping two hydrogen atoms off from the alcohol molecule thereby converting the alcohol molecule into a molecule of acetaldehyde says doctor Akoury. We are going to consider the three enzymes progressively in this article.

Nicotinamide Adenine Dinucleotide (NAD): The Three Alcohol Enzymes

The three enzymes which can convert alcohol to acetaldehyde are:

  • Alcohol dehydrogenase (ADH) ·
  • Cytochrome P450 (CYP2E1) ·
  • Catalase

Each of these enzymes is found in different parts of the body and each of them handles the hydrogen atoms which are stripped off from the alcohol molecule in a different way. For the purpose of this article, we are going to discuss the first one and proceed with the rest of the subsequent postings.

Alcohol dehydrogenase

The name “alcohol dehydrogenase” sounds quite a mouthful, but it is self-explanatory if we break it down into its component parts. “de-” is a prefix which means “to remove”. We find it in such words as “dethrone” which means “to remove from the throne”. “-use” is a suffix which means “enzyme”. Any time you see a chemical term which ends in the suffix “-as” you know that you are dealing with an enzyme. “hydrogen” means “hydrogen” of course. So “de-hydrogen-ase” means “an enzyme which removes hydrogen atoms”, and “alcohol dehydrogenase” means “an enzyme which removes hydrogen atoms from the alcohol molecule”. The name alcohol dehydrogenase is sometimes abbreviated to ADH.

ADH is the workhorse of the alcohol enzymes–it breaks down the majority of the alcohol that enters the human body. Alcohol dehydrogenase is actually the name for a family of enzymes which break down alcohol–each of which has a slightly different molecular structure. Researchers have identified as many as 10 varieties of the alcohol dehydrogenase molecule. All of them bring about the same chemical reaction–the difference is that some varieties of alcohol dehydrogenase work more efficiently than others. As we shall be seeing later, these variations in the alcohol dehydrogenase molecule can explain why some individuals react differently to alcohol than others.

The alcohol dehydrogenase molecules do their work primarily in the stomach and the liver, although traces of them are found in other tissues as well. The hydrogen which is released when alcohol dehydrogenase turns alcohol into acetaldehyde is bound to a compound called NAD+ (Nicotinamide Adenine Dinucleotide) to form NADH (this is short for Nicotinamide Adenine Dinucleotide plus Hydrogen). Alcohol dehydrogenase does its work in the cellular fluid (cytosol) of the cell. The wordings in this article may be technical but necessary in understanding the dangers of substance abuse. You may want to seek for more clarity from the experts at AWAREmed today.

Nicotinamide Adenine Dinucleotide (NAD): Acetaldehyde and Alcoholism




Mitochondrial Rejuvenation

Fibromyalgia with IV NAD and Mitochondrial Rejuvenation

MitochondrialMitochondrial plays very crucial in the body. Mitochondria are the powerhouse of the body as it is where energy is made. They are organelles that take in nutrients, break them down, and create energy rich molecules for the cell. Many of the reactions involved in cellular respiration happen in the mitochondria. Mitochondria are the working organelles that keep the cell full of energy. Different cells have different amounts of energy. While there are cells that have no mitochondrion, the muscle cells need to have lots of these mitochondria as they need lots of energy to accomplish their functions. Neurons are also important in the body and they too need good amount of mitochondria to serve their purposes, however they do not need as much mitochondria as the muscle cells. These organelles are very vital in the cells as they generate energy which is the mostly utilized by the cells therefore any dysfunction within the mitochondria can cause serious problems such as fatigue which is a common symptom of those suffering from chronic fatigue and fibromyalgia. Recently researchers have been able to establish a link between mitochondrial dysfunction and fibromyalgia. Findings of researchers are pointing at mitochondrial dysfunction as a possible cause of fibromyalgia.

Fibromyalgia is a disorder characterized by widespread muscle pain, joint stiffness, and fatigue. The condition is chronic but pain comes and goes and moves about the body. The cause of this disorder is unknown and therefore it is often misdiagnosed or unrecognized and is most of the times complicated by anxiety and mood disorders. this is a common disorder that according to the American College of Rheumatology diagnosis criteria affects about 3-5% of women, most of whom are between ages 20 and 50, but only 0.5- 1.6% of men. This disease is more common in adults than in children but it affects women more than men. The exact cause of fibromyalgia isn’t yet known but researchers have been trying to join dots and come up with explanations to support the possible causes that they have come up with. Mitochondrial dysfunction is one of the possible causes that have been stated by many researchers.

About 6 years ago, researchers showed that the muscles of fibromyalgia patients did not have adequate amounts of mitochondria. these researchers also noticed that even the shape of mitochondria in the muscle tissues of the fibromyalgia patients was irregular as compared to control subjects who were in the of the same age. However these findings were not explained and this prompted biologists from Spain known as Mario Cordero, Ph.D. and Placid Nava’s, Ph.D., to begin looking into an enzyme that is needed by the mitochondria: Co-Enzyme-Q10 (CoQ10). CoQ10 is an essential enzyme for detoxifying or neutralizing nasty waste products produced by the cells. The wastes that are produced by the cells are often reactive oxygen species since they react with and degrade anything that they come in contact with. Higher levels of reactive oxygen species have been found in patients with fibromyalgia and the higher levels tend to correspond to more pain. Just a year ago Cordero and Nava’s found that the CoQ10 content in the blood cells of fibromyalgia patients was 40 percent less than age-matched healthy control subjects. However, in the nutrient-rich liquid portion of the blood, the CoQ10 concentration for fibromyalgia patients was double that of the healthy controls. This imbalance in distribution of this enzyme has made Cordero and his team to do more research and establish the cause of this imbalance. These researchers noticed that the level of ROS was higher in fibromyalgia patients and this leads to programmed destruction of mitochondria.

When the levels of ROS are elevated it will lead to more tissue damage, nerve irritation. The imbalance in CoQ10 and loss of mitochondria could be linked to other symptoms that commonly occur in fibromyalgia. A reduction in mitochondria could lead to muscle weakness, more fatigue, and less ability to tolerate physical activities without flaring with more pain and exhaustion. This therefore means that if mitochondria can be rejuvenated then it can help in reducing the pain as well as support fibromyalgia treatment.

Rejuvenating Mitochondria with IV NAD

MitochondrialNAD is an abbreviation of Nicotinamide adenine dinucleotide. It is a coenzyme that is present in all living cells. The compound is a dinucleotide; this simply means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively. The NAD and the NADH are crucial in the production of energy in the mitochondria. What happens after eating is that the vitamins, minerals, carbohydrates, proteins and fats from our diet provide the building blocks to our bodies. Energy that is produced from citric acid cycle makes NAD and links it to hydrogen forming NADH which enters the electron transport chain in the mitochondria and is sparked with oxygen which breaks the nutrients to give energy through oxidation. This energy enables the heart to beat sufficiently and enable muscle contraction providing cellular energy that is required by the body cells to function. In fibromyalgia patients the level of mitochondria is low plus they are deformed. when a patient is put through an IV NAD therapy the level of NAD in the body is going to be high hence will be utilized in making energy in the mitochondria and help quell fatigue. NAD is also known to remove toxins like ROS that accumulate in the cells leading to programmed mitochondrial damage.

Finally, Here at AWAREmed we advocate for good health and wellness and proclaim freedom from chains of diseases. Dr. Dalal Akoury is an experienced integrative doctor who has been helping patients suffering from different conditions to live positively. Visit us at Myrtle Beach, South Carolina for help.

Fibromyalgia with IV NAD and Mitochondrial Rejuvenation



IV Niacin Is a Safe Treatment for Addiction

IV Niacin Is a Safe Treatment for Addiction

Niacin also known as vitamin B3 has been used for a long time for treating myriads of diseases. However, the Niacin therapy has been used mostly for the treatment of depression and anxiety. Unfortunately, most of us have never heard of the potential emotional benefits of Niacin. Though the reason for secrecy surrounding vitamin therapy has a complicated and deep-rooted past, a simple explanation is that natural remedies are not supported by the U.S medical field and so this is a reason why the niacin therapy for treatment of addiction especially the withdrawal symptoms are not welcomed or well known in the United States. To many people living in the United States the only thing they know about niacin is that; having enough niacin or vitamin B3, in the body is important for general good health. As a treatment, higher amounts of niacin can improve cholesterol levels and lower cardiovascular risks. They only relate niacin to improvement of cholesterol levels hence mitigating on the effects of lower cholesterol levels. That is the bit that is known by many people around the world but the truth is there is more to niacin or vitamin B3 than just improvement of the cholesterol levels in the body. Researchers have found out that intravenous niacin can be used for treatment of addiction related complications such as depression and anxiety that are common withdrawal symptoms of many drugs.

History of Niacin use in fighting depression and anxiety

IV NiacinDepression and anxiety are some of the most severe symptoms that most addicts have to grapple with. It is because of depression that most addicts find it hard to quit using their drugs of abuse. Whenever an addict tries to stop using the drugs they will face depression and this will make them sink in to drug use to find escapade. History has proved that niacin is effective in fighting depression. The founder of AA, Bill Wilson who had been struggling with chronic depression found relief when he become a part of a study which involved use of niacin as a cure for depression. The study was led by psychiatrists Humphrey Osmond and Abram Hoffer. It was done in the late fifties and that success marked a good publicity for the use of niacin in treatment of depression. After his success, Bill gave niacin use unwavering support and published many articles detailing his experiences with depression and how he got cure in niacin. These can be found in his book titled “Pass it on”.

Despite this success in the fifties there has been few prescription of niacin to patients, this owing to the myth that niacin use is dangerous catapulted by  patients had taken the Niacin to clear their system of Cocaine in order to pass drug tests but instead experienced serious reactions with higher doses of the niacin. In spite of all this, a handful of enlightened doctors have been using niacin to treat their patients suffering from chronic depression. It is quite unfortunate that even with proven effectiveness in treatment of chronic depression and other illnesses the use of vitamin therapy places doctors at a risk since in the United Sates prescribing a nutritional therapy or vitamin therapy is against the law.

Treating Drug withdrawal symptoms; Depression and Anxiety Naturally

IV NiacinNiacin not only treats depression, but has also been shown to aid with sleeping problems, addiction, arthritis, schizophrenia, and high cholesterol. When a person has been using the drugs of pleasure for a long time they affect the balance of the brain chemicals. In most cases long term use of drugs causes depletion of niacin and its deficiency is first evident in brain-related symptoms of poor concentration, difficulty focusing, and attention deficit disorders. Niacin contains NAD which is important for energy production, so shortage of niacin leads to energy shortage which if lasts long enough, brain neurons cannot synthesize neurotransmitters. When this occurs, the molecules of consciousness such as serotonin, dopamine, and noradrenaline are affected. Anxiety, depression, sleep disturbance and other mood changes can then arise. These are not good for addicts as they may trigger them to use drugs as escapade. Therefore having an IV niacin therapy will help in supplementing NAD in the body.  This will not only increase the production of energy but will also increase the level of NADH which is critical for enzymatic action. The IV Niacin goes straight to receptors in the brain and so is not digested in the stomach. NAD is also metabolic co-enzyme and is charged with the important job of structuring, repairing, and remodeling every cell in the body that are destroyed by the long term drug use.

Depression and anxiety are not the only problems associated with drugs but are some of the most severe effects of long term drug use and so should be taken seriously. Niacin therapy helps with treatment of depression induced by drug addiction however be sure to find help from a qualified medical doctor.

And finally, we at AWAREmed Health and Wellness Resource Center are committed to finding the best treatment for addicts. We have qualified doctors who will see to it that every addict is helped to break the bond of addiction and enjoy life of freedom. Dr. Dalal Akoury (MD) is committed to availing help to every patient. Call on her at Myrtle Beach, South Carolina for help.

IV Niacin Is a Safe Treatment for Addiction


St. John’s Wort Helps in Depression and Insomnia Treatement

St. John’s Wort Powers: The Treatment of Depression and Insomnia during Addiction Withdrawals

St. John’s Wort is a wonder plant that has been used in treatment of many conditions for quite a long time. The most used part of this herb is the flowers and the leaves. This herb has many medically active components but its known most active components are two; hypericin and hyperforin. Although hypericin was formerly thought to be the component of St. John’s wort principally responsible for its action, it is now understood that hyperforin, adhyperforin, and several other related compounds are the primary active constituents. Both hyperforin and adhyperforin appear to modulate the effects of serotonin, dopamine, and norepinephrine and may inhibit reuptake of these neurotransmitters. This herb has been found to be very useful in treatment of conditions that are caused as a result of imbalances in the neurotransmitters.

St. John’s Wort for Depression during addiction withdrawals

Imbalances in the neurotransmitters such as serotonin and dopamine cause depression. This imbalance may be caused by use of drugs of pleasure or by other diseases. Apart from these two causes, a person may also have a family history of depression and so predisposed to depression a case which makes it rather complicated for the brain to produce the neurotransmitters in required amounts. The brain has a great role to play in inhibiting depression; it has to produce the millions of chemicals it produces in the right amounts everyday failure to which you will be depressed. It’s that complicated.

In the long-term, all drugs and alcohol are brain depressants. In moderate amounts, alcohol does not lead to depression, but abusing drugs or alcohol will definitely lead to depression. This is because they deplete your brain of serotonin and dopamine. Researchers warn that it may take quite a long time for depleted dopamine to be restored and so it is important to avoid abusing drugs.

Alcohol abuse almost doubles the risk of depression. In one study that looked at 2,945 alcoholics. Fifteen percent were depressed before they began abusing alcohol, and that number jumped to 26 percent after they started abusing alcohol. Once they stopped drinking for an extended period, 15 percent remained depressed. This study showed that alcohol almost doubles the risk of depression.

St. John’s Wort

Marijuana has also been linked to depression. It is reported that marijuana users are four times more likely to develop depression. In one study which monitored a large group of people for 16 years, it was discovered that people who smoked marijuana were four times more likely to develop depression.  Another study followed later with 1601 students and confirmed the findings. Depression is a serious illness that may make it hard for an addict to stop taking the drugs of pleasure to boost the dopamine levels for a moment. Fortunately this can be helped by use of St. John’s Wort. Taking St. John’s wort extracts improves mood, and decreases anxiety and insomnia related to depression.  This herb seems to be effective in treatment of mild depression than some of prescription drugs.  According to the American College of PhysiciansAmerican Society of Internal Medicine, St. John’s wort can be considered an option along with antidepressant medications for short-term treatment of mild depression.

St. John’s Wort for Insomnia during addiction withdrawals

According to National Sleep Foundation, insomnia is difficulty falling asleep or staying asleep, even when a person has the chance to do so. People with insomnia can feel dissatisfied with their sleep and usually experience the symptoms of poor sleep that may deter them from enjoying healthy lifestyles. This disease can affect people of all ages but adults are the major victims.

A person suffering from insomnia may show the following symptoms

  • Irritability, depression or anxiety
  • Difficulty paying attention, focusing on tasks or remembering
  • Increased errors or accidents
  • Tension headaches
  • Distress in the stomach and intestines (gastrointestinal tract)
  • Ongoing worries about sleep
  • Difficulty falling asleep at night
  • Awakening during the night
  • Awakening too early
  • Not feeling well rested after a night’s sleep
  • Daytime tiredness or sleepiness


Insomnia may be caused by depression and stress but it may also be caused by the imbalances in the neurotransmitters as a result of long term use of drugs of pleasure.  Some other causes of insomnia include;

Anxiety– Anxiety is a common everyday problem. However there are more serious anxiety disorders like PTSD which will never give your brain a rest. Anxiety beckons insomnia and so should be avoided to help you sleep soundly and reap huge health benefits from it.

Medical conditions-there are conditions that cause insomnia. These conditions may include; chronic pain, chest problems and even frequent urination. These conditions may cause difficulty in sleep. Diseases like cancer, arthritis, heart disease, stroke, Alzheimer’s disease and even Parkinson’s disease have been linked to insomnia.

St. John’s wort has been found to be very effective in treatment of depression that might cause difficulty in sleep and this is owed to its effects on serotonin may be primarily responsible for its antidepressant activity. Apart from being an anti-depressant this herb works on the neurotransmitters in unlimited ways it affects many neurotransmitters that are key to good sleep health.

Drug induced Insomnia may not be easy to treat. However there are also medical approaches to treating drug induced Insomnia but of all these going the natural way is much better since it has less side effects and is more effective.  We at AWAREmed health and wellness center are dedicated to finding the best natural solutions to health problems. You can visit us at Myrtle Beach South Carolina where you will be attended to by Dr. Dalal Akoury (MD) who has vast experience in integrative medicine for lifestyle diseases.

St. John’s Wort and treatment of depression and insomnia during addiction withdrawals