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Inflammatory Neurodegenerative Disorders

Adipose Derived Stem Cells to Treat Inflammatory Neurodegenerative Disorders

There are very many neurodegenerative disorders that we humans have to battle with. Some of these neurodegenerative disorders are inflammatory. Inflammation is a common feature in some neurodegenerative diseases such Alzheimer’s disease (AD) and multiple sclerosis. Microglial cells, the resident macrophages of the central nervous system, become chronically activated and mediate pathology inducing inflammatory responses. This inflammation may be initiated as an immune response and while it does not cause the disease, it has been shown to aggravate the progression of the inflammatory neurodegenerative diseases. Contrary to what many people think, inflammation does not initiate neurodegenerative disease but there is evidence that chronic inflammation involving microglia and astrocytes contribute to disease progression. The inflammatory response has been implicated in Alzheimer’s disease, Parkinson’s disease and MS. Currently, a major question is whether inhibition of the inflammatory response has the ability to reverse or slow the symptoms of disease.

Typically, inflammation is a defense mechanism against diverse insults, designed to remove noxious agents and to inhibit their detrimental effects. It consists of an astounding range of molecular and cellular mechanisms and an intricate network of controls to keep them in check. In neurodegenerative diseases, inflammation may be triggered by the accumulation of proteins with abnormal conformations or by signals emanating from injured neurons. Given the multiple functions of many inflammatory factors, it has been difficult to pinpoint their roles in specific pathological situations. Studies of genetically modified mice and of molecular pathways in activated glia are beginning to shed light on this issue. Through different studies it has been found that altered expression of different inflammatory factors can either aggravate or counteract neurodegenerative processes. Normally, inflammation should be beneficial but for some reasons inflammation in neurodegenerative disorders can form grounds for aggravation of these neurodegenerative disorders and so a viable means of treatment that should suppress inflammation and inhibit progression of these disorders should be utilized to help in treatment of these inflammatory neurodegenerative disorders.

Adipose Derived Stem Cells

Inflammation and Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disease that is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. According to a new study, there are markers of inflammation in the cerebrospinal fluid that protects the brain and spine from injury. This study linked these markers to symptoms like fatigue, depression and anxiety in patients with Parkinson’s disease and it is hoped that this discovery may make the treatment of this disease much easier.

This study was led by Lena Brundin who is an associate professor at the College of Human Medicine at Michigan State University. This research was carried out as part of a team from Lund University in Sweden, Skåne University Hospital in Sweden and the Mayo Clinic College of Medicine in Jacksonville, Florida. The team measured a number of inflammatory markers in fluid samples of patients with Parkinson’s and in a control group without the disease.

“The degree of neuroinflammation was significantly associated with more severe depression, fatigue, and cognitive impairment even after controlling for factors such as age, gender and disease duration.” Prof. Brundin told the press.

However this is not the first study to link brain inflammation to Parkinson’s disease, there are previous studies that have linked it to non-motor symptoms like depression, fatigue and cognitive impairment. These past studies have indicated that inflammation in the brain could drive cell death, and drugs that target this process could offer new treatments to slow progression of the disease. For instance, a study published as far back as 2007 suggested that brain cell death in Parkinson’s may be reduced by blocking enzyme activity.

According to Prof. Brundin most of these previous studies looking at inflammatory markers in the cerebrospinal fluid of Parkinson’s patients have involved only small numbers of patients, often without comparing them to healthy controls. Despite this view, it is still evident that brain inflammation still has a role to play in aggravating neurodegenerative disorders.

Inflammation and Multiple Sclerosis

Multiple sclerosis is a disease of the Central Nervous System that is characterized by demyelination and inflammation. In a nutshell, MS is often described as an inflammatory demyelinating condition. Myelin is a layer of fatty that covers the nerves maintaining their health and flexibility. It is demyelination that causes spasms that are common with MS patients.

Adipose Derived Stem Cells

Adipose derived stem cell therapy for these inflammatory neurodegenerative disorders

Owing to the ability of the stem cells to differentiate many times and form different body cells, they have been used in the past to regenerate or better yet to replace damaged cells in the body and this has made them a target for treatment of vey many conditions, including neurodegenerative disorders.

The stem cell therapy is now being used to grow dopamine producing nerve cells in laboratories to aid the treatment of this disease. The stem cells are majorly used in the labs when the genetic cause of the disease is known. The disease destroys cells but through stem cells therapy, the damaged cells can be replaced by healthy new cells of the same type. There are also researchers who have since done extensive work in applicability of stem cell therapy in treating PD. through research it has been shown that by releasing various kinds of noxious factors such as cytokines or proinflammatory molecules microglia may damage CNS cells. The stem cell therapy can be used to restore the parts of the nervous system that are destroyed as a result of release of cytokines in inflammatory neurodegenerative disorders.

Finally, Neurodegenerative disorders have debilitating effects on patients and should be fought by all means. This is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to patients by availing integrative and safe treatment options to all our patients. In case you are troubled by any of these disorders, just call on Dr. Dalal Akoury (MD) today and begin your journey to victory against neurodegenerative disorders

Adipose Derived Stem Cells to Treat In Inflammatory Neurodegenerative Disorders

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Current Stem Cell Treatments for Orthopedic Conditions

Current Stem Cell Treatments for Orthopedic Conditions

The stem cells have a unique ability to divide and become more specialized cells forming cells like bone, blood, or muscle. It is this ability that makes them attractive agents in many areas of medicine.  They can therefore be used to fight very many diseases in the regenerative medicine. Another advantage of stem cell therapy treatments is that autologous stem cell transport is made possible. This means that a person may be treated by doctors harvesting the stem cells from the patient and having the stem cells reimplanted into the same patient after finding out what was lacking in the patient. This reduces risks of infection as well as rejection which are helpful to the patient.

Today the stem cell therapy has become the game changing approach to treatment of orthopedic conditions. The ability of these stem cells to differentiate into more specialized cells has made them a valuable target in treatment of musculoskeletal conditions. Particularly the use of bone marrow stromal cells has attracted the attention of researchers who are in pursuit of finding out how these stem cells can be applied to end human misery caused by some diseases.

Stem cells are a unique type of cells, unlike the other cells in the body the stem cell have the ability to self-renew, they have the ability to divide several times giving rise to differentiated cells which are suited for specific functions hence can be used to replace or regenerate worn out cells in the body causing pain and discomfort. They can form cardiac, liver, fat, bone, cartilage, nerve, and connective tissue cells among other more specialized cells. Autologous stem cell therapy harnesses the regenerative power of your body’s own stem cells as a treatment option for degenerative orthopedic conditions.

body_skeleton

Today there are hospitals that have embraced the use of stem cells therapy in treating orthopedic conditions that were rather not easily treated in the past.  They offer this autologous stem cell therapy, which embraces the regenerative power of mesenchymal stem cells to give patients another treatment option for dealing with orthopedic conditions such as osteoarthritis and other degenerative joint conditions.  Patients who have the following diseases can benefit from stem cell therapy;

  • Degenerative Joint Changes, Including Osteoarthritis
  • Disc-related Back Pain
  • Meniscus Tears
  • Non-Union Fractures
  • Avascular Necrosis
  • Bone Loss
  • Cartilage Defects
  • Osteonecrosis
  • Tendonopathies

Orthopedic Areas in which Stem Cell Therapy is applicable

Spine – the stem cell therapy is applicable in treatment of the degenerated intervertebral disk which is known to cause pain and morbidity to many patients. The stem cell therapy brings into the field of regenerative medicine some bits of effectiveness.  In treatment of spine, patients who fail to respond to conservative medicine are left with one option-surgery that may have limited success and is also very invasive. Cell-based tissue treatments, including mesenchymal stem cell injections for degenerative disc subjects have been shown to diminish the incidence of low back pain, with clinical results noting improvement in back pain and regeneration of the disc tissue. In cases where spinal fusions are necessary, the use of stem cells through bone marrow aspirate has shown greater success in obtaining fusion through bone formation as compared to standard fusion techniques. Daily the number of institutions using the stem cell therapy to treat orthopedic conditions is increasing.

Articular Cartilage – when the articular cartilage is damaged, the potential to repair it are limited and this can often lead to arthritic diseases many years later. This damage may be caused by injury. The vulnerability of the articular cartilage makes it important for it to be well handled in cases of injury. studies that have been done on the applicability of the stem cell therapy to repair damaged articular cartilage have shown that stem cell therapy have favorable outcomes in this area than current techniques of micro fracture and autologous chondrocyte implantation. Most studies use mesenchymal stem cells derived from the bone marrow.

orthopedic therapyOsteonecrosis – Osteonecrosis or avascular ischemia of the hip can be associated with progression to an advanced arthritic joint. Standard treatment for osteonecrosis has included cord decompression with limited results. Stem cell therapy holds key to success in this area of orthopedic treatment. Studies on this area have shown that patients treated with mesenchymal stem cells improved than those treated with cord decompression.

 Bone – some damages on the bone may require transplantation of the bone plus other bone components. This is the effective way of restoring the bone structure. Being that the mesenchymal stem cells can be differentiated into bone cells and be used to replace the damaged bone components, stem cell therapy becomes the most appropriate treatment for bone damage.

Tendons and Ligaments –  Autografts, allografts, and resorbable materials have been used to repair defects in tendons and ligaments however these methods puts the life of the patient at risk which may include formation of scars, donor morbidity and even tissue rejection. With autologous stem cell transplant all these risks are alleviated plus the mesenchymal stem cells may also be used alongside tissue allografts as this gives better results by improving the biochemical properties of the tissue allografts.

Stem cell therapy is a promising treatment for orthopedic diseases; you may tap into the unique medicinal properties of the stem cells to help you beat orthopedic conditions. Visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

Current Stem Cell Treatments for Orthopedic Conditions

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Stem Cell Therapy Used By Pro Athletes to Heal Injuries

Stem Cell Therapy Used By Pro Athletes to Heal Injuries

The intriguing medicinal abilities of the stem cell therapy seem to have got embraced by athletes.  today there are athletes who are using the stem cell therapy to help heal joint related injuries that they get in the course of playing their games and ultimately reduce their ability to play as well as they ought to. Stem cell therapy seems to be a game changing strategy in treating injuries that would rather be complicated treating with surgery alone. however despite the known benefits of the stem cell therapy and its exceptional relief it offers to patients given that it is the most versatile approach to treatment of diseases, It has not got into mainstream medical treatments for sports medicine and most of the time the teams do not pay for the costs incurred by athletes who opt to get treated through the stem cell therapy needless to mention it is still not recognized in the US. Despite these some athletes have chosen to tap into the immense potential of stem cell therapy to heal their respective injuries.

Chris Johnson, 28 is one of the many of NFL players who have opted to have their injuries a stem cell therapy treatment having heard of the amazing potential of the stem cell therapy when he visited orthopedic surgeon James Andrews in January, 2014 to fix his ailing left knee. Johnson had suffered a torn meniscus while in action for the Titans. When Dr. James Andrews presented him with the idea of stem cell therapy he decided to give it a try.

Knee injuries

“When I tore my meniscus and played the season out, through the wear and tear, I lost a lot of cartilage,” says Johnson, who was signed by the Jets to bring explosiveness to their offense. “When you put the stem cells in, it might be able to help rebuild that cartilage in your knee. Hopefully, it makes your knee better for even more years.” he adds.

Having agreed to have the therapy done, Johnson had stem cells siphoned from bone marrow with along needle from the iliac crest of his pelvis and had these stem cells injected directly on his injured knee. This was done with hopes that the stem cells will not only work as anti-inflammatory agents but also hasten the healing of the knee by repairing the torn meniscus.

Stem cell therapy is popular among NFL Players

Evidently, Johnson is not the only athletes who have used the stem cell therapy to heal his injury. Another Pro athlete, Peyton Manning is reported to have tried a stem-cell treatment in Europe in 2011, which was his final year with the Colts with an aim of fast-tracking his recovery from neck surgery.  another athlete, Prince Amukamara, Giants cornerback had a slow-healing broken metatarsal treated with stem cells by a foot specialist in North Carolina after his team’s Super Bowl XLVI run. One NFL linebacker paid $6,000 a pop for a 1-milliliter vial of donated placenta tissue containing stem cells to be injected into each of his beat-up knees this offseason but asked for his name not to be used in this story because he didn’t tell his team’s medical staff. This shows how amazing the stem cell therapy is in view of these pro-athletes.

It is reported that stem cell therapy has become more popular with NFL athletes, as it now stands, of the 32 teams, hundreds of the players have got stem cell treatment for their various injuries. This averages to six players per team which is impressive, however the stem cell therapy is still not a mainstream treatment and it still is somehow a shadow that is not understood by many. however, evidence of the stem cell therapy’s usefulness in treating athletes’ injuries is so far largely anecdotal, NFL teams often will not pick up the bill for players, and the overseas market for treatments not approved in the U.S. makes the whole field seem somewhat taboo but this has not discouraged the athletes which may mean that they have seen some benefits with the therapy.

Knee injuriesThe sports doctors have been recently pushing for the NFL teams to pick the bills that athletes incur while getting the stem cell therapy and to shun this view of stem cell therapy as farfetched. Dr. Andrews who is an expert in biologics – term refers to substances that are produced in living systems such as humans, animals and microorganisms, rather than manufactured like drugs is an important in this push. it is expected that when the US embraces the stem cell treatment for the athletes then the sport doctors like Dr. Andrews will be able to offer their star-studded clientele more of these treatments more effectively in the U.S. in this agenda the retired NFL players will be studied to prove how well the stem cell therapy works in treating arthritis of the knee, this is a more regenerating approach to treatment of injuries.

“We have had one big revelation in sports medicine over the last 50 years, and that was the arthroscope,” Andrews says. “I’ve been looking for the next wave, and I think the biologics, particularly stem-cell therapy and enhancement of the healing properties, will be it.”

“We’ve been saying that since the new decade of this new millennium, so we’re already behind.” he concludes.

Finally, Stem cell therapy is a promising treatment for orthopedic diseases; you may tap into the unique medicinal properties of the stem cells to help you beat orthopedic conditions. Visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

Stem Cell Therapy Used By Pro Athletes to Heal Injuries

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Stem Cells For Relieving Chronic Pain

Relieve Chronic Pain without Surgery with Stem Cell

Chronic pain can make your life unbearable. No one wants to be maimed by chronic pain. However there are conditions that may enslave you to chronic pain. Diseases such as cancer and arthritis are known to cause unbearable pains that must be mitigated failure to which the pain may beckon some other grievous conditions that may shorten your life in the long run. There has been various ways through which patients have been put on programs that help them mitigate on the effects of chronic pain. Some of the most common avenues through which chronic pain is managed are through the use of pain drugs such as the opioids. However the use of these drugs also poses a great challenge as the patient may become dependent on them and they can also be easily abused leading to addiction among other problems associated with narcotic drug use.  Apart from the use of these opioid to manage chronic pain there are also circumstances that a chronic pain patient may have to be put to surgery to help reverse the chronic pain and restore normal tissue functioning.

Well, today there are leading regeneration centers that have understood that there must be a better way of dealing with chronic pain. the frustrations that patients go through in search of a better treatment for their pain has put scientist on their heels, researching on better ways that are not only effective but also affordable. Today most regeneration centers dealing with chronic pain are focusing on providing innovative stem cell treatments to our patients in order to reinvigorate their quality of life without complex surgery that most patients maimed by chronic pain dread. With advanced technology, chronic pain patients are getting better treatment that is less invasive by the use of stem cell therapy.

chronic pain

Stem cell therapy can help in controlling your pain

Stem cell therapy is a highly beneficial treatment that aims to assist patients who typically suffer from chronic pain, take back control of their lives. Stem cells have contributed to the healing process of various patients with medical conditions that resulted in damage to the joints or nervous system. You will however need to find a reputable hospital or doctor who has experience in treating chronic pain with stem cell therapy to help you take back control of your life. Generally, the use of stem cell therapy in pain management has seen many patients of pain for example those maimed by osteoarthritis, back pain, rheumatoid arthritis, knee joint pain and rotator cuff syndrome get relief from pain and improve quality of their lives. Stem cell therapy is yet to replace the old ways of managing pain such as use of opioids that may make the patient addicted to them in the long run and surgery that is dangerously invasive and cause myriads of discomfort. Today, reputable doctors are utilizing stem cell therapy for patients suffering from osteoarthritis, neurological diseases and degenerative conditions. The pain treatment is now aimed at reducing pain, increasing strength, increasing flexibility, increasing mobility and energy of chronic pain patients that suffer from these conditions.

How is it done?

Chronic PainAs mentioned earlier, the stem cells are responsible for healing of the body, the body needs to have enough of these stem cells to be able to heal incases of acute pain. However the stem cells may get diminished as a person ages there by utilizing the power of stem cell therapy, the patient’s own stem cells can be harvested and injected right into the area where they are most needed. The process involves isolating these stem cells from a sample of the patient’s blood, bone marrow or adipose tissue and injecting them into the damaged body part to promote healing. Platelet-rich-plasma (PRP), a concentrated suspension of platelets (blood cells that cause clotting of blood) and growth factors, may also be used to assist the process of repair. The stem cell therapy works to repair the damaged tissues by utilizing the healing ability of undifferentiated cells that form all other cells in our bodies.

Before, the harvesting of the stem cells that are to be used in the treatment, a doctor will apply a local anesthetic in the area from which these stem cells will be harvested. After which, about 30-60cc of bone marrow stem cells or about 20cc of adipose-derived stem cells is extracted. What follows is separation of stem cells and the platelets from the rest of the body by the help of a centrifugal machine. Finally, the    Healthy stem cells and growth factors are then injected directly into the damaged area where they facilitate healing of the damaged tissues. After this stem cell injection, PRP injection may also be given after four to six weeks should there be need.

At AWAREmed Health and Wellness Resource Center we assist a wide variety of patients who suffer from chronic pain with our stem cell therapy. Chronic pain can be overbearing, draining, and leave you feeling hopeless. That’s why it’s important to remember that there is help available at AWAREmed Health and Wellness Resource Center. Our lead doctor, Dr. Dalal Akoury (MD) has a vast experience in the field of integrative medicine that pain patients can tap on for their own good. Call on her today at Myrtle Beach, South Carolina and find out how she can harness the power of stem cell therapy to help you win back control of your life.

Relieve Chronic Pain without Surgery with Stem Cell

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Safe Autologous Stem Cell Transplant for Diabetes

According to a recent WHO report, diabetes is one of the top ten leading causes of death worldwide; in 2012 the global prevalence of diabetes was estimated to be more than 10% among adults. The most prevalent type of diabetes is the type 2 and it is rampant in adult population. It is reported that diabetes is the leading cause of renal failure and blindness in developed countries, a person suffering from diabetes also has high chances of having a limb amputated. The risk of limb amputation is 10 times higher in diabetic patients. It is also known that most diabetic patients develop hypertension and cardiovascular diseases, which account for high rates of morbidity and mortality among adult patients. Most patients receive treatment through oral medication but this is also dangerous since after sometime they become insulin dependent. Oral insulin medication is also not so effective since exogenous insulin cannot provide the tight glycemic control exerted by the pancreas-derived insulin secretion. Due to these myriad problems stem cell therapy can be very useful in replacing the affected cells and restore normal cell function normalizing insulin levels in the long run.

What is autologous stem cell transplant?

The body has stem cells in the bone marrow, in muscle tissues and also in the adipose tissues.  These stem cells turn into red blood cells, white blood cells, or platelets to help your body stay healthy. However there are situations when the amount of stem cells in the body is not enough to keep you healthy. This may be caused by some diseases like multiple myeloma or by aging. When this happens there will be need for supplementing the amounts of the stem cells so that they can be able to offer protection to your body. This calls for stem cell transplant which may be done by placing healthy stem cells in your body through an IV to restore the normal functions of the stem cells. at times the stem cells may be harvested from outside the body especially from placentas after successful normal delivery, however when this stem cells are sourced from within the body of the patient then it is referred to as autologous stem cell transplant. Autologous stem cell transplant is safer since the cells are from the body and therefore there is no risk of them getting rejected neither to induce unpleasant allergic reaction.

autologous stem cell transplant

How stem cells collected

In autologous stem cell transplants, the doctors use peripheral blood stem cell transplantation. With peripheral blood stem cell transplantation, the stem cells are taken from blood. The growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood. G-CSF is a protein that is produced naturally in the body. The blood is removed from a vein and passed through a machine that separates the stem cells. The machine then returns the remaining blood through a needle in the person’s arm or through a central venous catheter. This way of collecting stem cells is called apheresis. In adults, most autologous transplants use stem cells from blood. In a child, the decision whether to use cells from the bone marrow or the blood depends on the size of the child.

Mesenchymal stem cells work best for diabetes

In the past cell based therapy as used in treatment of diabetes began by use of islet transplantation have been successful in providing a source for insulin secreting cells. However this method has had its share of failures and disadvantages that created a vacuum that doctors hoped to be filled by a better cell based therapy. Some of the downs of the islet transplantations included; limited donors, graft rejection, the need for continued immune suppression and exhaustion of the donor cell pool. the search for a more reliable and sustainable source of insulin secreting cells made stem cell therapy a target as a promising alternative for islet transplantation in  diabetic patients who fail to control hyperglycemia even with insulin injection. Autologous stem cell transplantation may provide the best outcome for those patients, since autologous cells are readily available and do not entail prolonged hospital stays or sustained immunotoxic therapy. Among autologous adult stem cells, mesenchymal stem cells therapy has been applied with varying degrees of success in both animal models and in clinical trials.

autologous stem cell transplantCell-based therapies for diabetes mellitus had achieved lots of success with the application of islet transplantation from cadaveric donors, and the success of the Edmonton protocol back in 1999. Despite the success of islet transplantation in fighting diabetes more so for type 1, there were some drawbacks for example there was need to use immunosuppressive regime so as to favor graft acceptance and prevent rejection. It is with these loopholes that researchers sought to find better treatment with mesenchymal stem cells. Stem cell therapy is a solution to some of the drawbacks of islet transplantation especially the shortage of donors. Autologous stem cell therapy allows for a person’s on organs to be used in the transplant.

In autologous stem cell transplant the most effective mesenchymal stem cells are used to differentiate into insulin producing cells. The mesenchymal stem cells can be harvested in the bone marrows or in the adipose tissues where they are found in plenty. The mesenchymal stem cells have very many advantages when used as they have a high capacity to self-replicate and differentiate to bone and fat-forming cells and other tissue cells. They maintain the capacity of multilineage differentiation potential, both within and across lineage barriers. They are easy to cultivate and expand, and maintain pluripotentiality after prolonged culture conditions. For more information on diabetes, Visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

Safe Autologous Stem Cell Transplant for Diabetes

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